Rabbit Anti-Human Truncated Tau dGAE (297-391) Polyclonal Antibody
Tau is a microtubule-associated protein encoded by the MAPT gene and plays a vital role in stabilizing neuronal microtubules. In Alzheimer’s disease (AD) and related tauopathies, tau undergoes pathological modifications that lead to its aggregation into paired helical filaments (PHFs), forming neurofibrillary tangles—a hallmark of AD.
A truncated tau fragment comprising residues 297–391, known as Tau dGAE, represents a minimal core region capable of self-assembling into PHF-like fibrils in vitro without the need for cofactors or templates. This 95-amino acid segment has been identified in the core of PHFs extracted from AD brain tissue and forms filaments that closely mimic those observed in human pathology.
Tau dGAE is a powerful model for studying the molecular mechanisms of tau aggregation, seeding, and propagation. Its ability to recapitulate key structural features of pathological tau makes it an essential tool for developing aggregation inhibitors, imaging agents, and immunotherapies targeting tau fibrils.
By isolating the aggregation-prone core of tau, researchers can dissect the structural transitions and biochemical interactions that drive neurodegeneration, making Tau dGAE a critical focus in Alzheimer’s disease research and therapeutic development.
This Rabbit Anti-Human Truncated Tau dGAE (297-391) Polyclonal Antibody is manufactured in Canada by StressMarq.
