Mouse Anti-Human Ankyrin R Monoclonal IgG2B Antibody
Ankyrin-R (ANK1), originally identified in erythrocytes, is a member of the ankyrin family of adaptor proteins that tether integral membrane proteins to the spectrin-actin cytoskeleton. This structural linkage is essential for maintaining plasma membrane stability and for the precise localization of ion channels, exchangers, and transporters across various cell types.
Although Ankyrin-R is best known for its role in red blood cells—where mutations cause hereditary spherocytosis—it is also expressed in the brain and muscle tissue. In neurons, Ankyrin-R contributes to the organization of membrane domains and supports the structural integrity of axons and dendrites. Its ability to bind β-spectrin and multiple membrane proteins suggests a broader role in maintaining neuronal polarity and excitability.
Recent studies have linked ANK1 dysregulation to Alzheimer’s disease, where altered expression patterns have been observed in affected brain regions. Epigenetic modifications of the ANK1 gene have been associated with neuroinflammation and neuronal vulnerability, positioning Ankyrin-R as a potential biomarker and contributor to disease progression.
As interest grows in the cytoskeletal underpinnings of neurodegeneration, Ankyrin-R is gaining recognition for its role in maintaining neuronal architecture and function. Understanding its molecular interactions and regulatory mechanisms may offer new insights into the pathogenesis of Alzheimer’s and related disorders.
This Mouse Anti-Human Ankyrin R Monoclonal IgG2B Antibody is manufactured in Canada by StressMarq.
