Mouse Anti-Human CD74 Monoclonal IgG1 Antibody
CD74, also known as the invariant chain, is a non-polymorphic type II transmembrane protein primarily recognized for its role as a chaperone for MHC class II molecules. It facilitates the proper folding, ER exit, and trafficking of MHC class II complexes to endosomal compartments, where it also contributes to peptide editing and antigen presentation.
While traditionally associated with professional antigen-presenting cells, CD74 expression extends to non-immune cells under inflammatory conditions, including epithelial and neural cells. This broader expression pattern has important implications for neuroinflammation and neurodegenerative disease.
Beyond its classical role, CD74 also functions as a high-affinity receptor for macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine implicated in neurodegenerative disorders such as Alzheimer’s disease and multiple sclerosis. CD74-MIF signaling activates downstream pathways involved in cell survival, immune activation, and neuroinflammation—key processes in the progression of neurodegeneration.
Notably, CD74 has a very short surface half-life (under 10 minutes), rapidly internalizing upon ligand binding. This property, combined with its restricted expression in healthy tissues, makes CD74 an attractive target for therapeutic intervention in both cancer and neuroinflammatory conditions.
As a molecule at the intersection of immune regulation and neuronal health, CD74 is gaining recognition as a critical player in the pathophysiology of neurodegenerative diseases.
This Mouse Anti-Human CD74 Monoclonal IgG1 Antibody is manufactured in Canada by StressMarq.
