Anti-SARS-CoV-2 Nucleoprotein
The Anti-SARS-CoV-2 Nucleoprotein is For Research Use Only
Target Species: SARS-CoV-2
Host Species: Human
Conjugate: Azide Free
Type: Monoclonal Antibody
Specificity: Nucleoprotein of SARS-CoV-2 (aa 11-19) which corresponds to the sequence RSAPRITFG of the N protein of SARS-CoV
Application: ELISA
Hybridoma: Phage display library
Clone: CR3018
Immunisation: Generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV.
Isotype: Human IgG1 Kappa light chain
Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage: Stable at +2-8°C for 12 months
Alternative Names: Nucleoprotein, SARS-CoV nucleoprotein, Nucleocapsid protein
Product Background
Coronaviruses are positive-sense RNA viruses having an extensive range of natural hosts and typically affect the respiratory system. SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins; the N protein holds the RNA genome, and the S, E, and M proteins together create the viral envelope. The N protein is multipurpose. It has two domains with different functions depending on the virus cycle. The first domain, located in the N terminal position, mainly acts in complex formation with the viral genome. The second domain, at the terminal C position, allows the self-assembly of the protein and facilitates the interaction of the M protein necessary for the constitution of the virion. In addition to its structural functions, the N protein seems to be involved in vitro on the infected host cell by disrupting these cellular regulatory pathways.
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