Rabbit Anti-Thymidine glycol Monoclonal IgG Antibody
Thymidine glycol (TG) is a prominent oxidative DNA lesion formed when deoxythymidine undergoes oxidation, either directly or via reactive intermediates such as thymidine chlorohydrin. As a stable and abundant product of oxidative stress, TG serves as a critical biomarker of DNA damage in both nuclear and mitochondrial genomes.
In the context of neuroscience, TG accumulation is increasingly recognized as a contributor to genomic instability in post-mitotic neurons, which are particularly vulnerable to oxidative damage due to high metabolic activity and limited DNA repair capacity. Elevated levels of TG have been detected in aging brain tissue and in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), where oxidative stress and impaired DNA repair are central pathological features.
TG lesions can interfere with DNA replication and transcription, leading to mutations, transcriptional arrest, and activation of DNA damage response pathways. If unrepaired, these lesions may trigger neuronal dysfunction, apoptosis, or chronic inflammation—key drivers of neurodegeneration.
Understanding the formation, repair, and biological consequences of thymidine glycol is essential for elucidating the molecular mechanisms underlying neuronal aging and degeneration. As a sensitive indicator of oxidative DNA damage, TG also holds promise as a diagnostic and prognostic biomarker in neurodegenerative disease research.
This Rabbit Anti-Thymidine glycol Monoclonal IgG Antibody is manufactured in Canada by StressMarq.
| Size | 100 µg |
| Group | |
| Alpha Chain | |
| Beta Chain | |
| Peptide | |
| Peptide Source | |
| Format | |
| Buffer | |
| Concentration | 1mg/mL |
| Storage | -20°C |
| Alternative Names | TG, Thymidineglycol |
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