Rabbit Anti-Rat NKCC2 Polyclonal Antibody

Rabbit Anti-Rat NKCC2 Polyclonal Antibody

NKCC2 (Na⁺-K⁺-2Cl⁻ cotransporter 2), encoded by SLC12A1, is a renal-specific transporter located in the thick ascending limb of the loop of Henle. Although classically associated with renal sodium reabsorption and targeted by loop diuretics, NKCC2’s role in the brain is gaining attention. Emerging studies suggest that NKCC2 may influence cerebrospinal fluid composition, neuronal excitability, and osmoregulation. Dysregulation of NKCC2 could contribute to altered ion gradients and excitotoxicity, processes implicated in neurodegenerative diseases such as Alzheimer’s and epilepsy. Understanding NKCC2’s extrarenal functions may uncover novel mechanisms of ion homeostasis and therapeutic opportunities in neurodegeneration.

This Rabbit Anti-Rat NKCC2 Polyclonal Antibody is manufactured in Canada by StressMarq.

Size	100 µg
Immunogen	Produced against a synthetic peptide mapping to a segment (amino acids 33-55) of the N-terminal tail of rat NKCC2 (antibody designation L224).
Immunogen Species	Rat
Host Species	Rabbit
Purification	Protein A Purified
Concentration	1 mg/mL
Specificity	Detects ~160kDa.
Alternative Names	SLC12A1, sodium potassium chloride cotransporter 2, sodium-potassium-chloride cotransporter isoform 2, BSC1, MBSC1, Na-K-2Cl cotransporter, NKCC2A variant A, RBSC
Storage	-20°C
SDS

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