Mouse Anti-Rat Slo2.2 Monoclonal IgG1 Antibody
Slo2.2, a member of the Slo potassium channel family, is a sodium-activated potassium channel that contributes to the regulation of resting membrane potential and neuronal excitability. Unlike Slo1, Slo2.2 is activated by intracellular Na⁺ and Cl⁻, linking its activity to ionic homeostasis and metabolic state.
This channel is thought to stabilize neuronal firing under conditions of high activity or metabolic stress, making it a potential modulator of excitotoxicity—a key feature of many neurodegenerative diseases. By dampening excessive excitability, Slo2.2 may protect neurons from calcium overload and oxidative damage.
Although still under investigation, emerging evidence suggests that Slo2.2 dysfunction may contribute to the pathophysiology of epilepsy, ischemia, and neurodegenerative disorders such as ALS and Alzheimer’s disease. Its unique activation profile and role in maintaining neuronal stability position Slo2.2 as a novel target for neuroprotective strategies.
This Mouse Anti-Rat Slo2.2 Monoclonal IgG1 Antibody is manufactured in Canada by StressMarq.
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