Mouse Anti-Rat mGluR1/5 glutamate receptor Monoclonal IgG2A Antibody
mGluR5 (metabotropic glutamate receptor 5) is a subtype of glutamate receptor that regulates synaptic transmission and plasticity via G-protein-coupled signaling. It is predominantly expressed in the hippocampus, cortex, and striatum—regions vulnerable to neurodegeneration.
Aberrant mGluR5 activity has been linked to excitotoxicity, calcium dysregulation, and neuroinflammation, contributing to the pathophysiology of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). mGluR5 also interacts with amyloid precursor protein and tau, influencing their aggregation and toxicity.
Pharmacological modulation of mGluR5 has shown promise in preclinical models, where antagonists reduce neuronal loss and improve cognitive outcomes. As a key regulator of glutamatergic tone, mGluR5 is a compelling target for therapeutic intervention in neurodegenerative disorders characterized by synaptic dysfunction and excitatory imbalance.
This Mouse Anti-Rat mGluR1/5 glutamate receptor Monoclonal IgG2A Antibody is manufactured in Canada by StressMarq.
