Mouse Anti-Human ERp57 (GRP58) Monoclonal IgG1 Antibody
ERp57, also known as PDIA3, is a thiol-disulfide isomerase involved in protein folding and quality control within the endoplasmic reticulum (ER). In the brain, ERp57 plays a critical role in maintaining proteostasis, particularly under conditions of ER stress—a key feature of neurodegenerative diseases.
ERp57 is upregulated in response to misfolded protein accumulation, as seen in Alzheimer’s, ALS, and prion diseases. It interacts with calnexin and calreticulin to assist in the proper folding of glycoproteins, including those involved in synaptic function and neuronal survival. Dysregulation of ERp57 impairs the unfolded protein response (UPR), contributing to neuronal dysfunction and cell death.
Given its role in mitigating proteotoxic stress, ERp57 is emerging as a potential therapeutic target for enhancing cellular resilience in neurodegeneration.
This Mouse Anti-Human ERp57 (GRP58) Monoclonal IgG1 Antibody is manufactured in Canada by StressMarq.
