Mouse Anti-Bovine KDEL Receptor Monoclonal IgG1 Antibody
KDEL receptors are key components of the endoplasmic reticulum (ER) protein quality control system, essential for maintaining cellular homeostasis. These receptors recognize and retrieve ER-resident proteins bearing the KDEL (Lys-Asp-Glu-Leu) C-terminal motif, preventing their loss during vesicular transport to the Golgi apparatus. Variants of the KDEL sequence also contribute to ER retention, reflecting the system’s adaptability.
In mammalian cells, three highly conserved KDEL receptor isoforms are localized to the cis-Golgi and ER-Golgi intermediate compartments. Functionally, KDEL receptors interact with ARF1 GTPase-activating proteins (GAPs), facilitating COPI-dependent retrograde vesicle transport. This retrieval mechanism is critical for sustaining ER function, especially under conditions of proteotoxic stress.
In the context of neurodegenerative diseases—such as Alzheimer’s, Parkinson’s, and ALS—chronic ER stress and impaired protein folding are central pathological features. Dysregulation of KDEL receptor function can disrupt the unfolded protein response (UPR), exacerbate protein misfolding, and contribute to neuronal dysfunction and degeneration.
Moreover, the KDEL receptor shares significant sequence identity with the yeast Erd2p, underscoring its evolutionary conservation and fundamental role in ER homeostasis. As interest grows in targeting ER stress pathways for therapeutic intervention, the KDEL receptor is emerging as a promising molecular target in neurodegenerative disease research.
This Mouse Anti-Bovine KDEL Receptor Monoclonal IgG1 Antibody is manufactured in Canada by StressMarq.
