Lipopolysaccharide (LPS) Binding Protein (LBP) is a type 1 acute phase protein that is
constitutively produced by the liver and rapidly upregulated during the acute phase response.
LBP plays a central role in the response to LPS. The protein catalyzes the monomerization of
LPS and its transfer to (s)CD14 and to lipoproteins. This way LBP has both a role in the
activation pathway of LPS: activation of monocytes by LPS leading to release of
inflammatory mediators and in the neutralization of LPS i.e. the uptake of LPS by lipoprotein
and subsequent clearing.
In plasma of healthy individuals LBP is present at levels of approximately 10 μg/ml, which
increase approximately 10-fold during acute phase responses.
This product is manufactured in Netherlands by Hycult Biotech.
| Size | 1 x 96 Well |
| Sensitivity | 4.4 ng/mL |
| Dynamic Range | 4.4 – 50 ng/mL |
| Incubation Time | 3 hours 30 minutes |
| Sample Type | Serum, Plasma, Cell Culture Supernatant |
| Storage | 2-8°C |
| Alternative Names | LBP |