CIC C1q ELISA Kit
The complement system is a biochemical cascade of the immune system that contributes to pathogen clearance, inflammation, opsonization, and immune complex removal. It consists of more than 30 soluble and cell-associated proteins that interact through a series of activation pathways. Complement proteins are produced primarily by hepatocytes, with additional production by immune and epithelial cells. C1q is a recognition component of the classical complement pathway and forms the C1 complex together with C1r and C1s. C1q recognizes immune complexes containing IgM or IgG antibodies bound to antigens, initiating activation of the classical pathway. C1q can also bind other altered or damaged structures, contributing to their recognition and clearance.
Circulating immune complexes (CICs) can interact with complement components such as C1q, and their measurement can be used to investigate immune complex formation and clearance. In research settings, C1q-binding assays are used to study immune complex-mediated processes and complement activation in experimental models of autoimmune, inflammatory, and immune-mediated conditions. Measurement of CIC C1q can provide information about circulating immune complexes that have the capacity to interact with C1q and can be evaluated alongside other complement markers to investigate complement-related mechanisms.
In clinical research, circulating immune complexes have been investigated in a variety of autoimmune and inflammatory conditions, including systemic lupus erythematosus and other immune-mediated diseases. Several methods have been developed for studying CICs, including precipitation-based, immunodiffusion, and complement-binding assays. Because immune complexes are heterogeneous and may differ in size, composition, and complement-binding properties, no single assay detects all types of circulating immune complexes. C1q-based measurements therefore provide a research tool for assessing a specific subset of immune complexes and investigating their relationship to complement activation and disease-associated immune responses.
This CIC C1q ELISA Kit is manufactured in Italy by Diametra.
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