Bovine Betacellulin

Bovine Betacellulin

$190.00

Bovine Betacellulin (BTC) is a heparin-binding growth factor belonging to the EGF family and consists of 80 amino acids. Synthesized as a transmembrane precursor, BTC is released as a soluble cytokine via proteolytic cleavage and contains one EGF structural motif. It binds to the epidermal growth factor receptor (ErbB-1), initiating dimerization with other ErbB family receptors to activate tyrosine kinase signaling pathways.

This research reagent is a 1:1 mixture of [Gly1] bovine betacellulin and Des [1-4] bovine betacellulin. For research use only. Not for diagnostic or therapeutic applications.

SKU: ARU100 Category: Tags: , ,

Bovine Betacellulin (BTC), a member of the EGF family, is an 80 amino acid heparin-binding protein. Like other members of the EGF family, it is synthesized as a transmembrane precursor. The soluble cytokine, containing one EGF structural motif, is released by proteolytic cleavage. BTC can bind to the EGF receptor (ErbB-1) which then dimerizes with another member of the ErbB receptor family to signal through the tyrosine kinase pathway. BTC is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells and is the only member of the EGF family to stimulate insulin secretion in pancreatic beta cells.

This product is a mixture of [Gly1] bovine betacellulin (50%) and Des [1-4] bovine betacellulin (50%).

This product is manufactured in Australia by GroPep Bioreagents.

Size 100 µg
Source Species Recombinant
Expression System Ecoli
Storage 2-8°C
Alternative Names Bovine Betacellulin, BTC

Product Citations