Anti-tissue transglutaminase (anti-tTG) IgG is an autoantibody directed against tissue transglutaminase, an enzyme that modifies gluten peptides and is central to the autoimmune response in celiac disease. While anti-tTG IgA is the preferred biomarker due to its higher sensitivity and specificity in individuals with normal immune function, anti-tTG IgG is particularly valuable in patients with selective IgA deficiency—a condition more common in those with celiac disease. In these individuals, IgG-based testing becomes essential for accurate diagnosis.
In clinical settings, anti-tTG IgG is used as a complementary test when total serum IgA is low or deficient. A positive anti-tTG IgG result in this context supports further diagnostic evaluation, such as intestinal biopsy or HLA typing. Though not as specific as its IgA counterpart, anti-tTG IgG can also help monitor disease activity and dietary compliance in certain cases. In research, anti-tTG IgG contributes to understanding the serologic variability in celiac disease and aids in developing improved diagnostic algorithms, particularly for seronegative or atypical presentations. It also helps explore the broader spectrum of gluten-related disorders and immune responses beyond classical IgA-mediated mechanisms.
This product is manufactured in Italy by Diametra.
| Size | 1 x 96 Well |
| Sensitivity | 0.12 AU/mL |
| Dynamic Range | 5 – 320 AU/mL |
| Incubation Time | 1 hour 15 minutes |
| Sample Type | Serum, Plasma |
| Storage | 2-8°C |
| Alternative Names | tTG, transglutaminase 2, TG2 |