Anti-dsDNA IgG ELISA Kit

$455.00

The Anti-dsDNA IgG ELISA Kit is for the quantitative measurement of IgG class antibodies directed against dsDNA in human serum or plasma. The Anti-dsDNA IgG ELISA Kit s intended for research use only and not intended for diagnostic procedures.

SKU: DCM095 Category: Tags: , , ,

Anti-double-stranded DNA (anti-dsDNA) IgG antibodies are highly specific autoantibodies directed against native double-stranded DNA, commonly associated with systemic lupus erythematosus (SLE). These antibodies are a hallmark biomarker of SLE and are included in classification criteria due to their strong association with the disease. Anti-dsDNA IgG is produced as part of an autoimmune response, and its presence reflects a loss of immune tolerance to nuclear components. These antibodies can form immune complexes that deposit in tissues, especially the kidneys, contributing to lupus nephritis and systemic inflammation.

In clinical practice, anti-dsDNA IgG is used for both diagnosis and disease monitoring in SLE. High titers often correlate with active disease, particularly renal involvement, making this biomarker useful for tracking flares and guiding immunosuppressive treatment. Quantification is typically performed using assays such as ELISA, Crithidia luciliae immunofluorescence, or radioimmunoassay. In research, anti-dsDNA IgG is a key tool for studying the pathogenesis of lupus, including mechanisms of autoantibody generation, immune complex formation, and end-organ damage. It also serves as a target in experimental therapies aiming to reduce autoantibody levels or block their pathogenic effects.

This product is manufactured in Italy by Diametra.

Size 1 x 96 Well
Sensitivity 0.135 IU/mL
Dynamic Range 12.5 – 200 IU/mL
Incubation Time 1 hour 45 minutes
Sample Type Serum, Plasma
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Anti-double-stranded DNA, Anti-native DNA, Anti-nDNA
Instructions For Use https://eaglebio.com/wp-content/uploads/2014/06/DCM095_Anti-dsDNA_IgG_ELISA_Kit_Package_Insert.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/03/DCM095_Anti-dsDNA_IgG_ELISA_Kit_SDS.pdf

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