Androstenedione Saliva ELISA Kit

Androstenedione Saliva ELISA Kit

Androstenedione is a steroid hormone produced primarily by the adrenal glands and gonads as an intermediate in the biosynthesis of testosterone and estrogens, including estrone and estradiol. It serves as a common precursor to both androgenic and estrogenic hormones and is secreted into the circulation, where it can be converted to testosterone and estrogens in peripheral tissues. Androstenedione has relatively weak androgenic activity compared with testosterone. Its production and secretion are particularly relevant to the study of adrenal and gonadal steroidogenesis and sex hormone regulation.

In research settings, measurement of androstenedione is used to investigate adrenal and gonadal function, steroid hormone biosynthesis, and androgen and estrogen metabolism. Androstenedione production varies with age, sex, and reproductive status. In premenopausal women, the adrenal glands and ovaries are important sources of circulating androstenedione, while production generally decreases after menopause, although the postmenopausal ovary remains a source of androstenedione. Measurement of androstenedione in saliva provides a non-invasive approach for investigating individual differences in steroid hormone concentrations and their relationship to circulating hormone levels.

In clinical research, androstenedione measurement is investigated as a biomarker of androgen production and steroidogenic activity in conditions involving altered adrenal or gonadal hormone synthesis. Changes in androstenedione concentrations may be studied in relation to disorders of androgen excess or deficiency and other endocrine conditions. Because salivary androstenedione has been reported to correlate with serum concentrations, saliva can be investigated as an alternative, minimally invasive specimen for hormone measurement. Interpretation of androstenedione levels alongside other steroid hormones can provide additional information about pathways involved in androgen and estrogen production.

This Androstenedione Saliva ELISA Kit is manufactured in Italy by Diametra.