ANA Screen ELISA Kit

$455.00

The ANA Screen ELISA Kit is for semiquantitative measurement of IgG antibodies directed against Sm (Smith), RNP/Sm, Scl-70, SS-A (Ro) (52kDa and 60kDa), SS-B (La), Jo1, U1-SmRNP, CENP-B, dsDNA and Histones in human serum or plasma. The ANA Screen ELISA Kit is for research use only and not to be used for diagnostic procedures.

SKU: DCM099 Category: Tags: , ,

The antinuclear antibody (ANA) screen is a broad serological test used to detect autoantibodies directed against various nuclear antigens. It is a key biomarker in the evaluation of systemic autoimmune diseases, particularly connective tissue disorders such as systemic lupus erythematosus (SLE), Sjögren’s syndrome, scleroderma, and mixed connective tissue disease. The ANA screen typically uses indirect immunofluorescence on HEp-2 cells, which allows visualization of different staining patterns (e.g., homogeneous, speckled, nucleolar) that can suggest specific autoantibody profiles and disease associations.
In clinical settings, the ANA screen is often the first-line test in patients with suspected autoimmune conditions due to its high sensitivity for SLE. A positive ANA result, especially at significant titers, supports further testing for specific autoantibodies (e.g., anti-dsDNA, anti-Sm, anti-Ro/SSA) that provide diagnostic and prognostic information. However, because ANA can also be positive in healthy individuals or those with non-autoimmune conditions, it must be interpreted in the context of clinical symptoms. In research, ANA screening is used to investigate autoimmunity mechanisms, identify novel nuclear antigens, and explore patterns of disease development and progression. It also helps stratify patient populations for studies targeting specific autoimmune pathways or therapeutic responses.

This product is manufactured in Italy by Diametra.

Size 1 x 96 Well
Sensitivity Cut-Off
Dynamic Range
Incubation Time 1 hour 15 minutes
Sample Type Serum, Plasma (heparin or EDTA)
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Antinuclear Antibody, Antinuclear Autoantibody
Instructions For Use https://eaglebio.com/wp-content/uploads/2014/06/DCM099_ANA_Screen_ELISA_Kit_Package_Insert.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/03/DCM099_ANA_Screen_ELISA_Kit_SDS.pdf

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