Alpha-B Crystallin ELISA Kit

Alpha-B Crystallin (CRYAB) is a small heat-shock protein primarily known for its role as a molecular chaperone. It prevents the aggregation of misfolded or denatured proteins under various cellular stress conditions. Highly expressed in tissues such as the lens, heart, skeletal muscle, and nervous system, CRYAB contributes to maintaining cytoskeletal integrity, regulating apoptosis, and modulating inflammatory pathways. Its expression increases in response to oxidative stress, ischemia, and mechanical injury, making it a key marker in stress-responsive biology.
In research settings, Alpha-B Crystallin is widely studied for its involvement in protein-folding disorders, neurodegeneration, cancer biology, and cardiac disease. Its anti-apoptotic and cytoprotective properties make it a target for understanding cellular resilience under stress. Researchers use CRYAB expression as an indicator of cellular stress, differentiation states, and myopathy progression, as well as a readout in models of multiple sclerosis, Alzheimer’s disease, and cardiomyopathies.
In clinical contexts, altered Alpha-B Crystallin levels have been associated with diverse pathologies, including neurodegenerative diseases, cataracts, cardiomyopathies, and certain cancers (e.g., breast and head-and-neck tumors). In oncology, CRYAB overexpression can correlate with tumor aggressiveness and poor prognosis, giving it potential as a diagnostic or prognostic biomarker. In cardiovascular and neuromuscular disease, detecting CRYAB can support the assessment of tissue injury, stress responses, or inherited myopathies. While not yet a routine clinical test, its expanding relevance in disease mechanisms continues to drive interest in its translational applications.

This product is manufactured in Canada by StressMarq.