“There were few studies of Zika virus (ZIKV), a
flavivirus, until this past year, when large epidemics
in the Americas were accompanied by
unexpectedly severe clinical manifestations. Infection
in pregnant women has emerged as a
major global concern because of its linkage to
congenital abnormalities including microcephaly,
spontaneous abortion, and intrauterine growth
restriction.1
In addition, ZIKV infection in other
age groups has been associated with severe neurologic
disease and the Guillain–Barré syndrome.” 
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Source:(https://www.nejm.org/doi/full/10.1056/NEJMcibr1605445?query=genetics&)