TK
210 ELISA, manufactured by AroCell is offered in EagleBio’s Cancer Biomarker Assay Line. The Cancer
Biomarker Assay Kit Line offered Eagle Biosciences provides a comprehensive
array of sensitive and valuable tools to assist researchers in new emerging
market segments in cancer research such as tumor marker and anti-tumor therapy
investigation.

Our TK
210 ELISA is a convenient, simple test as well as the most sensitive
ELISA for measuring TK1.

Why Measure Thymidine Kinase 1 (TK1)?

The enzyme Thymidine Kinase 1 (TK1) is up-regulated in
tumor cells from which it is released into the blood during their turnover.
Increased serum TK1 protein has been discovered to be associated with tumor
growth. TK1 up-regulation may be an early event in cancer development and TK1
may even be elevated in pre-cancerous conditions.¹

Although TK1 activity is a valuable biomarker it has
limitations in that most current methods are based on enzyme activity
assays.The AroCell TK 210 ELISA test, based on two monoclonal antibodies
specific for a unique TK1 amino acid sequence (194-225), brings the
specificity, sensitivity and robustness of immunoassay to the assay of serum
TK1.²

Key Advantages of TK 210 ELISA:

Most
Sensitive ELISA for measuring TK1
Simple
ELISA procedure with same day results
Accurately
measure both Active & Inactive TK1
Solid
tumors do not affect results unlike other methods for measuring TK1
Strong
Evidence that TK210 can be used successfully with traditional cancer
markers like CA15-3
Use
with both Serum or Tissue samples

Recent Citations:

View
Publications List

References:

1.Alegre,
M.M. et al. (2012). Thymidine Kinase 1 Upregulation Is an Early Event in Breast
Tumor Formation. Journal of Oncology. Volume 2012, 5 pages.

2.Kumar.
J.K. et al. (2016). A Clinical Evaluation of the TK 210 ELISA in Sera from
Breast Cancer Patients Demonstrates High Sensitivity and Specificity at All
Stages of the Disease. Tumor Biology. DOI 10.1007/s13277-016-5024-z (Epub ahead
of print)

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Product Highlights: Chromogranin A ELISA

by Eagle Biosciences

Chromogranin A ELISA

Chromogranin A ELISA is for Research Use Only.

Eagle Biosciences’ Chromogranin A ELISA in our Cancer Biomarker Assay Kit Line. The Cancer Biomarker Assay Kit Line offered Eagle Biosciences provides a comprehensive array of sensitive and valuable tools to assist researchers in new emerging market segments in cancer research such as tumor marker and antitumor therapy investigation.

Our Chromogranin A ELISA is one of the unique assays in the this Cancer Biomarker Assay Kit Line that offers excellent sensitivity, precise results in under 3 hours, and exclusive measurement of human chromogranin A without the high dose “hook” effect up to 1,000,000 ng/ml.

Why Measure Chromogranin A?

Chromogranin A (CgA) is a 49 kDa acidic protein that consists of 439 amino acids encoded on chromosome 14. It has been identified in a number of normal and neoplastic endocrine tissues. In fact, chromogranin A is a highly sensitive and specific marker for pheochromocytoma, carcinoids, and other neuroendocrine tumors (NET) [1]. Molina et. al describes “CgA is one of the most used tumor markers in NETs, and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors [2].”

The measurement of Chromogranin A provides incredible value to scientists studying numerous areas of cancer research beyond other biomarkers utilized for the detection, evaluation, and monitoring of specific tumor types.

Key Advantages of EagleBio’s Chromogranin ELISA, CHR31-K01

Excellent Sensitivity
Precise results under 3 hours
Measures CgA without the high dose “hook” effect up to 1,000,000 ng/ml.
Competitive Price

Recent Citations for EagleBio’s Chromogranin A ELISA

Conteduca et. al. Chromogranin A is a Potential Prognostic Marker in Prostate Cancer Patients Treated With Enzalutamide. Prostate. 2014 Dec;74(16):1691-6. PMID: 25262981.

Molina et al. Evaluation of chromogranin A determined by three different procedures in patients with benign diseases, neuroendocrine tumors and other malignancies. Tumor Biol. (2011) 32:13–2. PMID:20730520

Burgio SL.et. al. Chromogranin A predicts outcome in
prostate cancer patients treated
with abiraterone. Endocr Relat Cancer. 2014 May 8;21(3):487-93. PMID: 24741024

References:

1. Pirker RA et. al, Usefulness of chromogranin A as a marker for detection of relapses of carcinoid tumours. Clin Chem Lab Med. 1998 Nov;36(11):837-40. PMID: 9877088

2. Molina et al. Evaluation of chromogranin A determined by three different procedures in patients with benign diseases, neuroendocrine tumors and other malignancies. Tumor Biol. (2011) 32:13–2. PMID:20730520

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Unique, Early Biomarker for Cell Proliferation

by Eagle Biosciences

Introducing the TK 210 ELISA assay kit from AroCell, the most sensitive assay available for measuring Thymadine Kinase 1 (TK1). TK1 is a key enzyme in DNA replication and it is up-regulated in proliferating cells. Many studies have shown it to be a valuable cancer biomarker but most previous assays have been activity based and underestimate TK1 in solid tumors.&nbspRead More

TK 210 ELISA is for Research Use Only. Not for Use in Diagnostic Procedures in the US.

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EagleBio’s Serotonin ELISA Cited in a Michigan State University Study

by Eagle Biosciences

EagleBio’s Serotonin ELISA was used in a Michigan State Univeristy study (see citation below). This is a kit from our Neurobiology Assay Kit line. The Neurobiology Assay Kit line offered Eagle Biosciences provides a comprehensive array of sensitive tools to measure catecholamines and numerous neuroscience-related analytes on various types of samples.

Plasma serotonin levels were determined in this study using Eagle Biosciences’ Serotoinin ELISA:

Joshi, N. Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease. Toxicology. 2016; 365:9-16.

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Product Hightlights: Periostin ELISA Assay Kit

by Eagle Biosciences

Periostin ELISA is designed for the quantitative determination of human Periostin in serum and plasma and is for Research Use Only. This assay is part of Eagle Biosciences’ Bone Metabolism Line which is a comprehensive portfolio of assays for detecting and monitoring numerous biomarkers for the regulation of bone and mineral homeostasis, assisting researchers in various fields of study.

Highlights

• Extensively validated
• 7 human serum based standards and 2 controls
• CE registration in progress

Related Areas of Research:

Osteology, tissue repair, cardiovascular disease, oncology, respiratory disease

Learn More

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Metformin Plus Syrosingopine Effectively Combats Cancer Cells

by Eagle Biosciences

Bengtsson, M. Metformin Plus Syrosingopine Effectively Combats Cancer Cells. December 27, 2016 Retrieved from: www.reliawire.com.

“A combination of a diabetes medication and an antihypertensive drug effectively fights cancer cells, according to a team of researchers at the University of Basel. They also report that specific cancer cells respond to this combination of drugs.” Read More

Source: (https://reliawire.com/metformin-syrosingopine-cancer/)

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iLite® anti-CD20 ADCC Activity Set – Half Price kits for evaluation

by Eagle Biosciences

Take Advantage of Our Limited Time Special Offer

iLite® anti-CD20 ADCC Activity Set

Kits are 1/2 price!

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EagleBio’s New Drug Monitoring Assays

by Eagle Biosciences

Assays below are For Research Use Only.

EagleBio’s New Drug Monitoring Assays:

Eagle Biosciences is pleased to offer 3 new assays to the Drug Monitoring Assay Kit line which offers a unique grouping of products that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically antitumor therapeutic investigation and more.

- - NF alpha Neutralization Rate/Adalimumab ELISA Assay Kit
    - Simultaneously determination:
      - Free TNFα target antigen
      - Available therapeutic antibody Adalimumab
      - Adalimumab’s ability to neutralize TNFα
- - TNF alpha Neutralization Rate/Infliximab ELISA Assay Kit:
    - Simultaneously determination:
      - Free TNFα target antigen
      - Available therapeutic antibody Infliximab
      - Infliximab’s ability to neutralise TNFα
  - Deoxynivalenol ELISA Assay Kit
    - Unique Assay for Determination:
      - Deoxynivalenol in food and feed crops

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Washington Study Uses Eagle Biosciences’ Biotinlylated Insulin

by Eagle Biosciences

EagleBio’s Human Insulin, Biotinylated (Biotin-Insulin) was recently utilized in a Washington State University Study. This recombinant human insulin is a part of our Endocrine product line that offers a comprehensive product grouping of unique for measuring a variety of analytes for diabetes and obesity research.

Citation:

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

“Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice.”

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Anti-Inflammatory Drugs Might Someday Treat Depression

by Eagle Biosciences

Kappelmann, N. et al. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Molecular Psychiatry.2016 00, 1–9. https://dx.doi.org/10.1038/mp.2016.167

“In the future, a new class of anti-inflammatory drugs could be used to treat depression, say University of Cambridge researchers.

Drugs such as aspirin and ibuprofen treat inflammation, the body’s immune response to infections or pathogens. During an inflammatory response, immune cells flood the bloodstream with proteins known as cytokines.” Read More

Source: (https://edition.cnn.com/2016/10/18/health/anti-inflammatory-drugs-depression)