Mouse Anti-Mouse Versican Monoclonal IgG1 Antibody
Versican (chondroitin sulfate proteoglycan 2, or CSPG2) is a large extracellular matrix (ECM) proteoglycan that plays a pivotal role in neural development, plasticity, and disease. As a key structural component of the brain’s ECM, Versican contributes to the formation of hydrated, viscoelastic matrices that regulate cell proliferation, migration, and differentiation. Its modular structure—featuring hyaluronic acid- and glycosaminoglycan-binding domains, EGF-like repeats, a lectin-like sequence, and a complement regulatory protein-like domain—enables dynamic interactions with neural cells and signaling molecules.
Alternative splicing of the VCAN gene produces isoforms with distinct glycosaminoglycan modifications, influencing tissue-specific functions and pathological outcomes. In the central nervous system (CNS), Versican is increasingly recognized for its role in modulating neuroinflammation, glial scar formation, and synaptic remodeling—processes central to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis.
Versican-rich pericellular matrices, often co-localized with hyaluronan, can alter cell adhesion and morphology, facilitating neural cell motility and mitosis. These properties are critical in both developmental neurobiology and the maladaptive responses seen in CNS injury and degeneration. Emerging evidence also links Versican dysregulation to impaired neural repair and chronic inflammation, positioning it as a potential biomarker and therapeutic target in neurodegenerative disease research.
This Mouse Anti-Mouse Versican Monoclonal IgG1 Antibody is manufactured in Canada by StressMarq.
