Mouse Anti-Rat GluN2A Monoclonal IgG2b Antibody
NR2A (GRIN2A) is a subunit of the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel essential for synaptic plasticity, learning, and memory. NR2A-containing NMDA receptors are predominantly expressed in the postnatal and adult brain, where they contribute to fast synaptic transmission and long-term potentiation (LTP).
NR2A plays a critical role in calcium influx and downstream signaling cascades that regulate gene expression, synaptic remodeling, and neuronal survival. Alterations in NR2A expression or function have been implicated in neurodegenerative diseases such as Alzheimer’s disease, where NMDA receptor dysregulation contributes to excitotoxicity and synaptic loss.
In addition to its role in cognition, NR2A is involved in neurodevelopment and the fine-tuning of excitatory synaptic strength. Its interaction with scaffolding proteins and signaling molecules positions it as a key modulator of synaptic architecture and plasticity. Targeting NR2A-containing NMDA receptors offers a potential therapeutic strategy for modulating glutamatergic signaling in neurodegenerative and neuropsychiatric disorders.
This Mouse Anti-Rat GluN2A Monoclonal IgG2b Antibody is manufactured in Canada by StressMarq.
