Mouse Anti-Rat HCN2 (Clone S71) Monoclonal IgG1 Antibody
HCN2 is a member of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel family, widely expressed in both the central and peripheral nervous systems. It contributes to the generation of pacemaker currents (I_h) that regulate neuronal excitability, rhythmic firing, and synaptic transmission.
In the brain, HCN2 is particularly important for maintaining the excitability of thalamocortical and hippocampal neurons. Dysregulation of HCN2 has been implicated in several neurological and neurodegenerative disorders, including epilepsy, chronic pain, and Parkinson’s disease.
HCN2 dysfunction can lead to abnormal neuronal firing patterns, increased susceptibility to seizures, and impaired sensory processing. In neurodegenerative contexts, altered HCN2 expression may exacerbate network instability and contribute to cognitive and motor deficits.
Additionally, HCN2 channels are modulated by cyclic nucleotides such as cAMP, linking them to intracellular signaling pathways that are often disrupted in neurodegeneration. Their role in regulating neuronal excitability and plasticity makes HCN2 a promising candidate for therapeutic modulation in diseases characterized by circuit dysfunction and progressive neuronal loss.
This Mouse Anti-Rat HCN2 (Clone S71) Monoclonal IgG1 Antibody is manufactured in Canada by StressMarq.
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