ExoGAG Serum

ExoGAG Serum

The ExoGAG Serum precipitation reaction is based on the interaction between the precipitation solution and glycosaminoglycans located on the exosome surface. After a simple incubation, the exosomes can be isolated by a short centrifugation. This patented system allows the isolation of exosomes from a serum sample with a minimal amount of co-precipitated material, such as protein or genetic material (DNA, RNA, or microRNA).

Serum is the liquid component of the blood after the blood is allowed to clot. Then by centrifugation the clot is removed and also the cellular fraction (erythrocytes, leukocytes and thrombocytes). Serum does not contain the coagulation cascade factors.
Serum is a source of proteins, cell-free nucleic acids, extracellular vesicles (among them exosomes) and metabolites. Indeed, it can host exosomes from any cellular type of the body in both physiological and pathological conditions. Given this, serum is one of the major sources of exosomes for clinical applications, since liquid biopsies represent a low-invasive procedure.
Exosomes isolate from serum represent a good surrogate for the identification of informative biomarkers for disease diagnosis, prognosis and longitudinal monitoring.

This ExoGAG Serum is manufactured in Spain by Nexotech.