High Sensitive Human Fetuin-A ELISA Assay Kit Assay Kit
High-Sensitive Fetuin-A (hs-Fetuin-A) is a glycoprotein primarily synthesized by the liver and secreted into the bloodstream, where it functions as a multifunctional biomarker involved in metabolic regulation, inflammation, and vascular health. It belongs to the cystatin superfamily of protease inhibitors and acts as a systemic inhibitor of ectopic calcification by binding calcium and phosphate ions. Fetuin-A also plays a significant role in insulin signaling, as it can inhibit insulin receptor tyrosine kinase activity, linking it to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus.
In research settings, the measurement of hs-Fetuin-A—using high-sensitivity assays—allows for the detection of subtle variations in serum levels that may reflect early metabolic or inflammatory changes. Studies have explored its relationship with cardiovascular disease, non-alcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), where Fetuin-A serves as both a protective and pathogenic factor depending on the context. Elevated hs-Fetuin-A levels have been associated with insulin resistance and metabolic syndrome, while reduced levels are linked to vascular calcification and increased cardiovascular mortality in CKD patients.
In clinical applications, hs-Fetuin-A is being investigated as a potential biomarker for early diagnosis, disease monitoring, and risk stratification in metabolic and cardiovascular disorders. Its dual role—as an anti-calcification factor and a mediator of insulin resistance—makes it a valuable target for understanding the pathophysiology of cardiometabolic diseases. Incorporating hs-Fetuin-A measurements into clinical research may improve predictive models for disease progression and therapeutic response, ultimately guiding more personalized and preventive healthcare strategies.
This High Sensitive Human Fetuin-A ELISA Assay Kit Assay Kit is manufactured in USA by Eagle Biosciences.
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