Tag: Cancer

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Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

by Eagle Biosciences

Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer. Preclinical and clinical evidence links resistance to antiestrogen drugs in breast cancer cells with the overexpression and/or activation of various pro-oncogenic tyrosine kinases. Disruption of circadian rhythms by night shift work or disturbed sleep-wake cycles may lead to an increased risk of breast cancer and other diseases. Moreover, light exposure at night (LEN) suppresses the nocturnal production of melatonin that inhibits breast cancer growth. Read More

Source:(https://cancerres.aacrjournals.org/content/74/15/4099)

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Cancer treatment on a cellular level

by Eagle Biosciences

IMAGE

CREDIT: (CREDIT: BORDALLO AND MARTINS, NIELS BOHR INSTITUTE)

The most common treatments for cancer are radiation and chemotherapy. However they have side effects and also damage healthy tissues. Moreover, their effectiveness is limited when the cancer has spread through out the body. Researchers at the Niels Bohr Institute are therefore working to develop a gentler treatment that ‘tricks’ the cancer cells, which would absorb a cytotoxin and therefore be destroyed, while healthy cells would remain unaffected. The results are published in the scientific journal, Scientific Reports. Read More


(Source: https://www.eurekalert.org/pub_releases/2016-03/uoc–cto022916.php)

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Cancer-causing gene found in plasma may help predict outcomes for head and neck patients

by Eagle Biosciences


Trisha Wise-Draper, MD, PhD. (credit: Joe Fuqua, University of Cincinnati)


Researchers at the University of Cincinnati (UC) have discovered that a human cancer-causing gene, called DEK, can be detected in the plasma of head and neck cancer patients. DEK may help doctors understand how a person’s immune system could be used to treat cancer or predict outcomes for patients.


(Source:  https://www.eurekalert.org/pub_releases/2016-02/uoca-cgf021516.php)

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Could Polio be the Hero in the Fight Against Cancer?

by Eagle Biosciences

 

PVS-RIPO virus

 PVS-RIPO Virus

There has been much buzz about the recent studies performed at Duke University since it was featured on 60 minutes on March 29th. This research has been focused on genetically engineering the polio virus to use for therapy in patients with cancer, more specifically, glioblastoma. The basis of this experimental therapy surrounded the scientific hypotheses that viruses could target cancer with viruses. In fact, these are ideas that have been around for a hundred years or more. Scientists at Duke took the Polio virus and genetically modified it to remove the harmful sequence that causes paralysis and replaced it with a harmless cold virus sequence. This new polio virus (PVS-RIPO) was then injected directly into the brain of the patients in the clinical trial.

So far, their work has proven that this is very promising treatment for cancer patients because they were able to not only shrink the tumors in several patients in this study but also diminish them until they were completely cancer free. However, there were patients that were not so lucky and did pass away during the course of this clinical trial. The goal of this study was to determine the proper dosage of the virus and scientist did in fact gain valuable insight that will help to continue to prove that this immunotherapy and other like it.

 Read more

image above from www.cancer.duke.edu

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