Tag: Cancer Research

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Study Shows How BPA May Affect Inflammatory Breast Cancer

by Eagle Biosciences

        image credit: https://corporate.dukehealth.org

DURHAM, N.C. — The chemical bisphenol A, or BPA, appears to aid the survival of inflammatory breast cancer cells, revealing a potential mechanism for how the disease grows, according to a study led by researchers in the Department of Surgery at Duke University School of Medicine and the Duke Cancer Institute.

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Source: (https://corporate.dukehealth.org)

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Product Spotlight: TK210 (Thymidine Kinase 1) ELISA Assay

by Eagle Biosciences

 

TK
210 ELISA, manufactured by AroCell is offered in EagleBio’s Cancer Biomarker Assay Line. The Cancer
Biomarker Assay Kit Line offered Eagle Biosciences provides a comprehensive
array of sensitive and valuable tools to assist researchers in new emerging
market segments in cancer research such as tumor marker and anti-tumor therapy
investigation.

Our TK
210 ELISA is a convenient, simple test as well as the most sensitive
ELISA for measuring TK1.

Why Measure Thymidine Kinase 1 (TK1)?

The enzyme Thymidine Kinase 1 (TK1) is up-regulated in
tumor cells from which it is released into the blood during their turnover.
Increased serum TK1 protein has been discovered to be associated with tumor
growth. TK1 up-regulation may be an early event in cancer development and TK1
may even be elevated in pre-cancerous conditions.1

Although TK1 activity is a valuable biomarker it has
limitations in that most current methods are based on enzyme activity
assays.The AroCell TK 210 ELISA test, based on two monoclonal antibodies
specific for a unique TK1 amino acid sequence (194-225), brings the
specificity, sensitivity and robustness of immunoassay to the assay of serum
TK1.2

Key Advantages of TK 210 ELISA:

  • Most
    Sensitive ELISA for measuring TK1
  • Simple
    ELISA procedure with same day results
  • Accurately
    measure both Active & Inactive TK1
  • Solid
    tumors do not affect results unlike other methods for measuring TK1
  • Strong
    Evidence that TK210 can be used successfully with traditional cancer
    markers like CA15-3
  • Use
    with both Serum or Tissue samples

Recent Citations:

View
Publications List

 

References:

1.Alegre,
M.M. et al. (2012). Thymidine Kinase 1 Upregulation Is an Early Event in Breast
Tumor Formation. Journal of Oncology. Volume 2012, 5 pages.

2.Kumar.
J.K. et al. (2016). A Clinical Evaluation of the TK 210 ELISA in Sera from
Breast Cancer Patients Demonstrates High Sensitivity and Specificity at All
Stages of the Disease. Tumor Biology. DOI 10.1007/s13277-016-5024-z (Epub ahead
of print)