Vanin-1 is an epithelial ectoenzyme responsible for converting pantetheine into pantothenic acid (vitamin B5) and cysteamine. Research suggests that cysteamine release promotes oxidative stress and inflammation by inhibiting key antioxidants such as superoxide dismutase (SOD) and glutathione (GSH). Interestingly, Vanin-1 may also act as a sensor for oxidative stress, as its expression increases in response to oxidative conditions across various tissues, including renal tubular cells, particularly following ischemic or toxic injury.
Vanin-1 expression is most prominent in renal tubular epithelial cells and can be detected in urine following renal injury. Studies have identified urinary Vanin-1 as a highly sensitive early biomarker of renal tubular damage, outperforming conventional markers like KIM-1, NGAL, and NAG. Elevated urinary Vanin-1 levels have been observed in various models of kidney injury, including drug-induced acute kidney injury, obstructive nephropathy, diabetic nephropathy, and hypertensive or inflammatory conditions.
In both research and clinical settings, the Urine Vanin-1 Assay Kit is used to explore its role in immune regulation, inflammation, and cellular signaling. It serves as a valuable tool for investigating disease mechanisms, assessing therapeutic targets, and evaluating diagnostic or prognostic potential, particularly in the context of kidney-related diseases and oxidative stress conditions.
This product is manufactured in Austria by Biomedica.
| Size | 1 x 96 Well |
| Sensitivity | 9.6 pmol/L (= 500 pg/mL) |
| Dynamic Range | 0 – 1 200 pmol/L (= 0 – 62 500 pg/mL) |
| Incubation Time | 4.5 hours |
| Sample Type | Urine |
| Storage | 2-8°C |