Sex hormone-binding globulin (SHBG) is a glycoprotein primarily produced by the liver that binds tightly to sex hormones, especially testosterone and estradiol, regulating their bioavailability and activity in the body. By binding these hormones, SHBG controls the amount of free, or biologically active, hormone that can interact with target tissues. Levels of SHBG are influenced by factors such as age, sex, hormonal status, liver function, and metabolic conditions, making it a critical regulator of sex steroid hormone balance.
In clinical and research settings, SHBG is used as a biomarker to assess androgen and estrogen status, helping to diagnose and manage conditions related to hormonal imbalances such as polycystic ovary syndrome (PCOS), hypogonadism, and hormone-sensitive cancers. Measuring SHBG levels alongside total hormone concentrations allows for more accurate determination of free hormone levels, which are more predictive of clinical symptoms. Additionally, SHBG is studied in metabolic research because its levels are affected by insulin resistance, obesity, and liver disease, providing insight into the interplay between sex hormones and metabolic health.
This product is manufactured in USA by Eagle Biosciences.