Calcium ions acts as a global second messenger involved in the regulation of many aspects of cell function. S100 proteins are involved in sensing and transforming calcium signals to downstream cellular responses. S100 family members are located in the cytoplasm and/or nucleus of a wide range of cell types and involved in the regulation of cellular processes such as cell cycle progression and differentiation and inflammatory responses.
Several S100 members have been found to act as cytokines in inflammation, particularly in autoimmune skin conditions such as psoriasis. S100A4 may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered S100A4 gene expression have been implicated in tumor metastasis. Studies have shown that S100A4 is involved tumor progression and metastasis in various malignant tumors. It is suggested that S100A4 serves as a promising candidate biomarker for early diagnosis and prediction of metastasis in several types of cancer.
This product is manufactured in Netherlands by Hycult Biotech.
| Size | 1 x 96 Well |
| Sensitivity | 1.6 ng/mL |
| Dynamic Range | 1.6 – 100 ng/mL |
| Incubation Time | 3 hours 30 minutes |
| Sample Type | Serum, Plasma |
| Immunogen | |
| Source Species | |
| Specificity | |
| Expression System | |
| Clone | |
| Group | |
| Alpha Chain | |
| Beta Chain | |
| Peptide | |
| Peptide Source | |
| Format | |
| Buffer | |
| Concentration | |
| Storage | 2-8°C |
| Alternative Names | Metastasin |
| Instructions For Use | https://eaglebio.com/wp-content/uploads/2025/03/HK377_S100A4_ELISA_Kit_Package_Insert.pdf |
| MSDS | https://eaglebio.com/wp-content/uploads/2025/03/HK377_S100A4_ELISA_Kit_SDS.pdf |