Rat immunoglobulin A (IgA) is a key antibody isotype primarily involved in mucosal immunity, serving as a first line of defense against pathogens at mucosal surfaces such as the gut, respiratory tract, and urogenital tract. It plays a critical role in neutralizing toxins, preventing microbial adherence, and maintaining immune homeostasis. In rats, IgA is often studied as a model for understanding mucosal immune responses, as its production and regulation mirror many aspects of human mucosal immunity. Changes in IgA levels can reflect immune activation, infection, or dysregulation, making it a valuable biomarker in immunological studies.
Enzyme-linked immunosorbent assays (ELISAs) for rat IgA enable sensitive and specific quantification of this antibody in serum, plasma, or mucosal secretions. In research settings, rat IgA ELISAs are commonly used to study immune responses to vaccines, infections, or experimental treatments, particularly those targeting mucosal immunity. They can also be used to evaluate immunomodulatory therapies, gut microbiome interactions, or models of autoimmune and inflammatory diseases.
While primarily used in preclinical research, rat IgA measurement can provide insights translatable to clinical contexts, especially in understanding mucosal immune deficiencies or responses to immunotherapies. By monitoring IgA levels, researchers can assess immune competence, the effectiveness of vaccine strategies, or the impact of chronic infections or inflammatory conditions on mucosal antibody production, making it an important tool for both basic and translational immunology studies.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 7.938 ng/mL |
| Dynamic Range | 31.25 ng/mL – 1000 ng/mL |
| Incubation Time | 1 hour 10 minutes |
| Sample Type | Plasma, Serum, Urine |
| Storage | 2-8°C |
| Alternative Names | Immunoglobulin A, sIgA, secretory IgA, serum IgA, and alpha immunoglobulin. |