Normetanephrine is a primary metabolite of norepinephrine (noradrenaline), produced through the enzymatic action of catechol-O-methyltransferase (COMT). It circulates in plasma and is excreted in urine, serving as a stable biomarker of norepinephrine metabolism and sympathetic nervous system activity. Because normetanephrine reflects both baseline and stress-induced norepinephrine turnover, it is particularly useful in evaluating disorders characterized by excess catecholamine production, such as pheochromocytoma and paraganglioma. Sensitive measurement techniques, including high-performance liquid chromatography (HPLC) and mass spectrometry, allow precise quantification of normetanephrine in clinical and research settings.
In research, normetanephrine is used to study sympathetic nervous system function, cardiovascular regulation, and stress physiology. Its measurement enables researchers to assess norepinephrine metabolism, monitor the effects of pharmacological interventions, and investigate the pathophysiology of hypertension, heart failure, and stress-related conditions in both animal models and human studies. Normetanephrine levels also serve as an indicator of adrenergic activity, helping to explore neuroendocrine and autonomic regulation.
This product is manufactured in Germany by LDN.
| Size | 1 x 96 Well |
| Sensitivity | 17.9 pg/mL |
| Dynamic Range | 72 – 7,200 pg/mL |
| Incubation Time | 5 hours 30 minutes |
| Sample Type | Plasma |
| Storage | 2-8°C |
| Alternative Names | O-methylated norepinephrine, noradrenaline metabolite, or 4-hydroxy-3-methoxymandelic acid amine. |
