Myeloperoxidase (MPO) is an oxidative enzyme stored in the granules of neutrophils, which make up roughly 70% of circulating white blood cells. As part of the innate immune response, MPO catalyzes the formation of reactive oxidants using hydrogen peroxide (H₂O₂), producing highly microbicidal compounds capable of destroying bacteria, fungi, viruses, and mycoplasma. The MPO–H₂O₂ system is further enhanced by PMN elastase, making it a potent mechanism for pathogen clearance. Because MPO is released during neutrophil activation, its presence in bodily fluids serves as a sensitive marker of inflammatory activity.
In clinical and research settings, MPO measurement is particularly valuable for assessing inflammation in the gastrointestinal tract, where stool MPO levels reflect disease activity in conditions such as Crohn’s disease and ulcerative colitis. In urine, MPO can serve as an indicator of renal transplant rejection or renal inflammation. MPO is also associated with systemic oxidative stress, making serum levels relevant in studies of cardiovascular risk, metabolic disorders, and chronic inflammatory diseases. Additionally, MPO assessment in bronchial lavage or respiratory samples aids in differentiating between allergic and infectious asthma by identifying neutrophil-driven inflammatory responses.
The Immundiagnostik AG MPO enzyme immunoassay enables quantitative determination of MPO in urine and stool, supporting both diagnostic applications and research investigations into inflammatory pathways, oxidative stress, immune activation, and disease progression.
This product is manufactured in USA by Immundiagnostik AG.
