Albumin is the most abundant serum protein in mammals, including non-human primates, playing essential roles in maintaining oncotic pressure, transporting endogenous and exogenous ligands (e.g., fatty acids, hormones, metal ions), and acting as an antioxidant. Structurally, albumin is a ~66 kDa protein comprised of three α-helical domains and multiple disulfide bonds, which gives it a stable conformation and high binding capacity. ([BioMed Central][1]) In monkeys (e.g., *Macaca* species), genetic polymorphisms of albumin have been identified: for instance, rhesus macaque albumin exists in at least two variants (Mac A and Mac B) distinguished by a single amino-acid substitution that alters bilirubin-binding affinity. ([PubMed][2])
In disease models, albumin in monkeys can serve as an indicator of vascular or renal integrity. For example, in a glaucoma model using monkeys, retinal albumin was found to be significantly elevated in diseased eyes, likely due to blood-retinal barrier disruption and/or cellular uptake; this increase was positively correlated with the degree of glaucomatous damage. ([PMC][3]) Moreover, albuminuria (urinary albumin) has been used in cynomolgus monkeys as an early biomarker of nephrotoxicity, rising before classic markers like blood urea nitrogen. ([PubMed][4])
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### Uses in Research & Clinical Settings
**In research**, the Monkey Albumin ELISA Kit is valuable for quantifying albumin in monkey serum, plasma, or urine to monitor physiological or pathological changes in preclinical studies. For example:
* **Toxicology / nephrotoxicity studies**: When testing drug candidates in non-human primates, measurement of urinary albumin can act as a sensitive early biomarker of glomerular damage. ([PubMed][4])
* **Barrier integrity / vascular leakage models**: In models of eye disease (like glaucoma) or systemic inflammation, increases in tissue or extracellular albumin can indicate breakdown of vascular barriers, oxidative stress, or impaired clearance. ([PMC][3])
* **Pharmacokinetics / protein therapeutics**: Since albumin binds many compounds and influences their half-life, ELISA-based measurement of monkey albumin may be used to assess how drugs interact with endogenous albumin in primate models.
**In a (pre-)clinical context**, while the ELISA kit itself is “for research use only” (not diagnostic), data generated from monkey studies can inform translational applications. For instance, findings in primate models on albumin leakage (or hypoalbuminemia) can guide hypotheses about similar mechanisms in human disease (e.g., renal injury, vascular permeability). Also, understanding albumin polymorphisms in monkeys may help in interpreting inter-individual variations in pharmacokinetics of albumin-binding drugs when translating to human trials.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 1.795 ng/mL |
| Dynamic Range | 12.5-400 ng/mL |
| Incubation Time | 1 hour 40 minutes |
| Sample Type | Biological Fluids |
| Storage | 2-8°C |
| Alternative Names | 1. This product is also known as the Hamster CHO MMP-19 Quantitative ELISA Kit. 2. This product is also referred to as the Hamster CHO MMP19 Immunoassay Kit. 3. This product is also called the Hamster CHO Matrix Metalloproteinase-19 Detection Kit. 4. This product is likewise known as the Hamster CHO MMP-19 Sandwich ELISA Kit. 5. This product may also be described as the Hamster CHO MMP-19 Protein Assay Kit. 6. This product is alternatively termed the Hamster CHO MMP-19 Antigen ELISA Kit. 7. This product is also labeled as the Hamster CHO MMP-19 Enzyme Immunoassay Kit. |