Human Lambda ELISA Kit
Lambda (λ) light chains are one of the two types of immunoglobulin light chains produced by plasma cells, the other being kappa (κ). These light chains combine with heavy chains to form complete antibodies, playing a central role in the adaptive immune response. Normally, small amounts of free lambda light chains circulate in the blood and are excreted in urine. However, abnormal production or accumulation of lambda chains is associated with plasma cell disorders, such as multiple myeloma, light chain amyloidosis, and other monoclonal gammopathies. Measuring lambda light chains provides insight into B-cell activity, immunoglobulin production, and the balance between normal and pathological plasma cell function.
The lambda ELISA (enzyme-linked immunosorbent assay) is a sensitive and specific method for quantifying free lambda light chains in serum, plasma, or urine. In research settings, lambda ELISAs are used to study the regulation of immunoglobulin synthesis, B-cell biology, and the mechanisms underlying plasma cell disorders. They are also employed to evaluate the effects of experimental drugs on plasma cell activity and to model disease progression in preclinical studies.
In clinical applications, lambda ELISA is commonly used to aid in the diagnosis and monitoring of plasma cell dyscrasias, including multiple myeloma and AL amyloidosis. Elevated serum or urine lambda light chain levels can indicate clonal plasma cell proliferation, and serial measurements help assess disease progression, treatment response, and risk of relapse. Combining lambda and kappa light chain measurements, as well as the kappa/lambda ratio, provides a more comprehensive picture of immunoglobulin abnormalities and is critical for accurate diagnosis and management of monoclonal gammopathies.
This Human Lambda ELISA Kit is manufactured in USA by Eagle Biosciences.
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