C1q ELISA Kit

$950.00

The C1q ELISA Kit is for the quantitative determination of human C1q and Ig containing circulating immune complexes (CIC) in serum, plasma, and bronchoalveolar lavage fluid (BALF). The C1q ELISA Kit is for research use only and not to be used for diagnostic procedures.

C1q, a key player in the classical complement pathway, seamlessly bridges innate and adaptive immunity. As part of the C1 complex, along with C1r and C1s, it activates upon binding to antibody-antigen complexes. This vital function positions C1q as an essential mediator in immune response management. Beyond activation, C1q recognizes IgG or IgM antibodies, initiating classical pathway activation through critical conformational changes. Its ability to bind apoptotic cells enhances immune clearance, preventing overstimulation.

Predominantly produced by macrophages and dendritic cells, C1q is pivotal in maintaining host defense and preventing autoimmune diseases like systemic lupus erythematosus (SLE). C1q deficiencies, whether genetic or from anti-C1q antibodies, impair apoptotic cell clearance, heightening SLE risk. This correlation is evident in conditions like proliferative glomerulonephritis and SLE flares, where C1q levels are notably low. The C1QA gene polymorphism, associated with reduced C1q levels, highlights its integral role in immune regulation. C1q’s significance extends to its diagnostic potential in understanding complex immune diseases, making it a vital biomarker in immunological research.

This product is manufactured in Netherlands by Hycult Biotech.

Size 1 x 96 Well
Sensitivity 7.8 ng/mL
Dynamic Range 7.8 – 500 ng/ml
Incubation Time 3 hours 30 minutes
Sample Type Serum, Plasma, Bronchoalveolar Lavage Fluid (BALF)
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Complement Component 1q
Instructions For Use https://eaglebio.com/wp-content/uploads/2025/03/HK356_C1q_ELISA_Kit_Package_Insert.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/03/HK356_C1q_ELISA_Kit_SDS.pdf

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