Anti-PR3 (c-ANCA) ELISA Kit

$580.00

The Anti-PR3 (c-ANCA) ELISA Kit is for the quantitative measurement of IgG class autoantibodies against proteinase 3 (PR3) in human serum or plasma. The Anti-PR3 ELISA Kit is intended for research use only is not intended for diagnostic procedures.

SKU: DCM091 Category: Tags: , , , ,

Anti-proteinase 3 (anti-PR3) antibodies are a subtype of anti-neutrophil cytoplasmic antibodies (ANCAs), specifically directed against proteinase 3, a serine protease located in the azurophilic granules of neutrophils and monocytes. Anti-PR3 is most commonly associated with granulomatosis with polyangiitis (GPA), a form of ANCA-associated vasculitis (AAV). These autoantibodies are believed to play a pathogenic role by activating neutrophils, promoting endothelial damage, and contributing to inflammation in small- to medium-sized blood vessels. The presence of anti-PR3 is a key biomarker for diagnosing GPA and can be detected using immunoassays such as ELISA or indirect immunofluorescence.
In clinical settings, anti-PR3 serves not only as a diagnostic tool but also as a prognostic marker. High titers of anti-PR3 are typically correlated with disease activity and may help guide treatment decisions and monitor for relapse. In research contexts, anti-PR3 is studied for its role in the immunopathogenesis of vasculitis and as a potential therapeutic target. Ongoing studies are investigating the mechanisms by which PR3 and its corresponding autoantibodies contribute to immune dysregulation, aiming to develop more targeted immunotherapies for ANCA-associated diseases.

This product is manufactured in Italy by Diametra.

Size 1 x 96 Well
Sensitivity 0.13 AU/mL
Dynamic Range 10 – 160 AU/mL
Incubation Time 2 hours
Sample Type Serum, Plasma
Storage 2-8°C
Alternative Names Anti-Proteinase 3, PR3-ANCA, c-ANCA, cytoplasmic ANCA, Anti-serine protease 3

Product Citations