Eagle Biosciences is thrilled to introduce the Anti-MyD88 L265P Antibody to our product lineup! This powerful tool can significantly enhance your lymphoma research.

Application

MyD88 L265P is a prevalent driver mutation in B-cell lymphomas, contributing to oncogenic signaling by activating BTK, HCK, NFkB, and JAK-STAT3 pathways. This mutation is linked to a poor prognosis and is frequently observed in:

90% of Waldenström’s macroglobulinemia (WM) cases
50-80% of IgM monoclonal gammopathy of undetermined significance (IgM-MGUS) cases
29% of diffuse large B-cell lymphomas (DLBCL) cases

WM and the aggressive activated B-cell-like (ABC) subtype of DLBCL remain incurable, making the tumor-specific MyD88 L265P mutation a valuable prognostic marker and a promising target for novel therapies.

Background

The MyD88 gene encodes a cytosolic adapter protein vital for both innate and adaptive immune responses. This protein acts as a crucial signal transducer in the interleukin-1 and Toll-like receptor signaling pathways, which regulate the activation of numerous proinflammatory genes. The protein includes an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene are more susceptible to pyogenic bacterial infections. Multiple transcript variants result from alternative splicing.

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