Eagle Biosciences Blog | EagleBio

Washington Study Uses Eagle Biosciences’ Biotinlylated Insulin

EagleBio’s Human Insulin, Biotinylated (Biotin-Insulin) was recently utilized in a Washington State University Study. This recombinant human insulin is a part of our Endocrine product line that offers a comprehensive product grouping of unique for measuring a variety of analytes for diabetes and obesity research.

Citation:

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

“Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice.”

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Anti-Inflammatory Drugs Might Someday Treat Depression

by Eagle Biosciences

Kappelmann, N. et al. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Molecular Psychiatry.2016 00, 1–9. https://dx.doi.org/10.1038/mp.2016.167

“In the future, a new class of anti-inflammatory drugs could be used to treat depression, say University of Cambridge researchers.

Drugs such as aspirin and ibuprofen treat inflammation, the body’s immune response to infections or pathogens. During an inflammatory response, immune cells flood the bloodstream with proteins known as cytokines.” Read More

Source: (https://edition.cnn.com/2016/10/18/health/anti-inflammatory-drugs-depression)

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EagleBio’s Norepinephrine ELISA Assay Kit in Nebraska Study

by Eagle Biosciences

Eagle Biosciences Norepinephrine ELISA Assay Kit was utilized in a recent Nebraska study (see below):

Shyra, Sundar Nandi et al. Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase. Diabetes 2016 Oct; 65(10): 3075-3090. https://dx.doi.org/10.2337/db16-0023.

“MicroRNAs (miRNAs) have a fundamental role in diabetic heart failure. The cardioprotective miRNA-133a (miR-133a) is downregulated, and contractility is decreased in diabetic hearts. Norepinephrine (NE) is a key catecholamine that stimulates contractility by activating β-adrenergic receptors (β-AR). NE is synthesized from tyrosine by the rate-limiting enzyme, tyrosine hydroxylase (TH), and tyrosine is catabolized by tyrosine aminotransferase (TAT).” Read More

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AroCell signs distribution agreement with Eagle Biosciences in the United States

by Eagle Biosciences

AroCell AB (publ) announced today that a distribution
agreement has been signed with the New England-based company Eagle
Biosciences, for distribution of the AroCell TK 210 ELISA test in North
America.

The TK 210 ELISA test measures TK1 protein levels for valuable
information about the speed of cell turnover. As tumors have high cell
turnover, the test may provide valuable information for prognosis and
optimization of treatment strategy.

“We are delighted to partner with Eagle Biosciences for the
distribution of the TK 210 ELISA test”, states Jan Stålemark, AroCell
CEO. “Eagle Biosciences is a leading provider of ELISA assay kits in
North America, and has primary focus on providing innovative products
that aid medical research and clinical laboratories. This highly concurs
with our strategy to make the TK 210 ELISA test widely available for
investigational use in the US, in order to facilitate use of the product
in cancer research institutions as well as within the pharmaceutical
industry”.

The TK 210 ELISA test will be commercially available immediately
through Eagle Biosciences for investigational use only in the United
States. The product can be found on the Eagle Biosciences website through the following link:

TK 210 ELISA

About AroCell

AroCell AB (AROC) is a Swedish company that develops
standardized modern blood tests to support the prognosis and follow up
of cancer patients. AroCell’s new technology is based on patented
methods to measure TK1 protein levels, which provide valuable
information about the speed of cell turnover. A tumor has high cell
turnover (speed of cell division and cell death) and as a result TK1 can
be detected in the blood with a simple laboratory test, called TK 210
ELISA. The test provides valuable clinical information for prognosis and
optimization of treatment strategy. The test may also be used for
monitoring disease relapse. For more information, please see www.arocell.com.
This information is information that AroCell is obliged to make public
pursuant to the EU Market Abuse Regulation. The information was
submitted for publication, through Jan Stålemark, at 11:45 CET on 6^th October 2016. Redeye is AroCell:s Certified Adviser

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Rates of Neonatal Abstinence Syndrome Amid Efforts to Combat the Opioid Abuse Epidemic

by Eagle Biosciences

Image result for Rates of Neonatal Abstinence Syndrome Amid Efforts to Combat the Opioid Abuse Epidemic

image credit: currentsinbiology.tumblr.com

Brown JD, Doshi PA, Pauly NJ, Talbert JC. Rates of Neonatal Abstinence Syndrome Amid Efforts to Combat the Opioid Abuse Epidemic. JAMA Pediatr. Published online September 26, 2016. doi:10.1001/jamapediatrics.2016.2150.

The United States is experiencing a rapid increase in neonatal abstinence syndrome (NAS) caused by in utero exposure to prescription and illicit (heroin) opioids.1,2 Increases in NAS correlate with the well-documented increase in prescription opioid abuse.3 State and federal policy efforts to combat this increase in drug abuse have halted the increase in prescription drug abuse but are associated with an increase in illicit drug use.3 Read More

Source: (https://archpedi.jamanetwork.com/article.aspx?articleid=2556200)

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Texas Study Utilizes EagleBio’s DM1 Antibody Drug Conjugate (ADC) ELISA

by Eagle Biosciences

EagleBio’s DM1 Antibody Drug Conjugate (ADC) ELISA ASSAY Kit was recently used in a Texas Tech University Health Sciences Center study. This assay is part of our Drug Monitoring Assay Kit line which offers a unique grouping of assays that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically antitumor therapeutic investigation and more.

Yao H-P, Feng L, Zhou J-W, Zhang R-W, Wang M-H. Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment. American Journal of Cancer Research. 2016;6(5):937-956. PMID:27293990

“Blood samples were collected at different time intervals. DM1-coupled Zt/g4 was measured using a DM1 antibody ELISA kit (EagleBiosciences, Inc., Nashua, NH).”

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Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears

by Eagle Biosciences

Figure thumbnail fx1

image credit: Graphical Abstract, Authors
Jonathan J. Miner, Abdoulaye Sene,
Justin M. Richner, Gregory D. Ebel,
Michael S. Diamond, Rajendra S. Apte

Miner et al., Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears, Cell Reports (2016), https://dx.doi.org/10.1016/j.celrep.2016.08.079

“Zika virus (ZIKV) is an emerging flavivirus that causes congenital abnormalities and Guillain-Barré syndrome. ZIKV infection also results in severe eye disease characterized by optic neuritis, chorioretinal atrophy, and blindness in newborns and conjunctivitis and uveitis in adults. We evaluated ZIKV infection of the eye by using recently developed mouse models of pathogenesis. ZIKV-inoculated mice developed conjunctivitis, panuveitis, and infection of the cornea, iris, optic nerve, and ganglion and bipolar cells in the retina.” Read More

Source: (https://www.cell.com/cell-reports/abstract/S2211-1247(16)31175-5)

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EagleBio’s Calprotectin ELISA Used in Recent NYU Study

by Eagle Biosciences

Eagle Biosciences’ Calprotectin ELISA was recently utilized in an NYU study. The researchers presented this abstract in a poster presentation at DDW 2016.

Citation:

The Use of Fecal Calprotectin to Understand the Expanded Utility of IBD Clinical Disease Activity and Quality of Life Assessments in Crohn’s Disease and Ulcerative Colitis

David Hudesman, Arun Swaminath, Dana J. Lukin, Mitchell Bernstein, Lisa Malter,
Melissa H. Rosen, Garrett Lawlor, Matthew Gross, Zoya Grigoryan, Arielle Radin, Michael
Tuen, Alexandra Feathers, Martin J. Wolff, Eve Frangopoulos, Martin J. Blaser, Huilin Li,
Lea Ann Chen

Fecal calprotectin levels were determined by EagleBio’s Calprotectin ELISA. The Eagle Biosciences Calprotectin ELISA Assay kit is intended for use in the quantitative determination of human calprotectin (neutrophil cytoplasmic protein S100A8/A9, MRP 8/14) levels in stool samples via Enzyme-linked immunosorbent assay. This assay kit is for research use only and should not be used in diagnostic procedures. Learn More

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Study Finds Potential New Biomarker for Cancer Patient Prognosis

by Eagle Biosciences

Image Credit:ZOSIA ROSTOMIAN/BERKELEY LAB

Study finds potential new biomarker for cancer patient prognosis

“To treat or not to treat? That is the question researchers at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing” Read More

Source:(https://www.eurekalert.org/pub_releases/2016-08/dbn. ).

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New Immunogenecity Symposium: October 5-7, 2016

by Eagle Biosciences

The 4th Coral Gables Symposium

Biltmore Hotel, Miami, FL

October 5-7, 2016

This years´ Coral Gables Symposia will provide a unique forum for thought leaders to address the principal concerns regarding immunogenicity and the patient. In particular, how an understanding of the immune response to biopharmaceuticals can benefit the patient both in terms of optimizing therapy, mitigating side effects, and improving outcome.