Author: Eagle Biosciences

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Product Hightlights: Periostin ELISA Assay Kit

by Eagle Biosciences

 

Periostin ELISA is designed for the quantitative determination of human Periostin in serum and plasma and is for Research Use Only. This assay is part of Eagle Biosciences’ Bone Metabolism Line which is a comprehensive portfolio of assays for detecting and monitoring numerous biomarkers for the regulation of bone and mineral homeostasis, assisting researchers in various fields of study.

Highlights

• Extensively validated
• 7 human serum based standards and 2 controls
• CE registration in progress

Related Areas of  Research: 

Osteology, tissue repair, cardiovascular disease, oncology, respiratory disease

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Metformin Plus Syrosingopine Effectively Combats Cancer Cells

by Eagle Biosciences
Metformin Plus Syrosingopine Effectively Combats Cancer Cells

Bengtsson, M.  Metformin Plus Syrosingopine Effectively Combats Cancer Cells. December 27, 2016 Retrieved from: www.reliawire.com.

“A combination of a diabetes medication and an antihypertensive drug effectively fights cancer cells, according to a team of researchers at the University of Basel. They also report that specific cancer cells respond to this combination of drugs.”   Read More


Source: (https://reliawire.com/metformin-syrosingopine-cancer/)




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EagleBio’s New Drug Monitoring Assays

by Eagle Biosciences

 Assays below are For Research Use Only.

EagleBio’s New Drug Monitoring Assays:

Eagle Biosciences is pleased to offer 3 new assays to the Drug Monitoring Assay Kit line which offers a unique grouping of products that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically antitumor therapeutic investigation and more.

      • NF alpha Neutralization Rate/Adalimumab ELISA Assay Kit
        • Simultaneously determination:

          • Free TNFα target antigen
          • Available therapeutic antibody Adalimumab
          • Adalimumab’s ability to neutralize TNFα
      • TNF alpha Neutralization Rate/Infliximab ELISA Assay Kit:
        •  Simultaneously determination:
          • Free TNFα target antigen
          • Available therapeutic antibody Infliximab
          • Infliximab’s ability to neutralise TNFα
      • Deoxynivalenol ELISA Assay Kit
        • Unique Assay for Determination:
          • Deoxynivalenol in food and feed crops
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Washington Study Uses Eagle Biosciences’ Biotinlylated Insulin

by Eagle Biosciences
Washington Study Uses Eagle Biosciences’ Biotinlylated Insulin

 

 

EagleBio’s Human Insulin, Biotinylated (Biotin-Insulin) was recently utilized in a Washington State University Study. This recombinant human insulin is a part of our Endocrine product line that offers a comprehensive product grouping of unique for measuring a variety of analytes for diabetes and obesity research.

Citation:

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

“Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice.”

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Anti-Inflammatory Drugs Might Someday Treat Depression

by Eagle Biosciences

Kappelmann, N. et al. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Molecular Psychiatry.2016 00, 1–9. https://dx.doi.org/10.1038/mp.2016.167

“In the future, a new class of anti-inflammatory drugs could be used to treat depression, say University of Cambridge researchers.

Drugs such as aspirin and ibuprofen treat inflammation, the body’s immune response to infections or pathogens. During an inflammatory response, immune cells flood the bloodstream with proteins known as cytokines.” Read More

Source: (https://edition.cnn.com/2016/10/18/health/anti-inflammatory-drugs-depression)

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EagleBio’s Norepinephrine ELISA Assay Kit in Nebraska Study

by Eagle Biosciences


Eagle Biosciences Norepinephrine ELISA Assay Kit was utilized in a recent Nebraska study (see below): 

Shyra, Sundar Nandi et al. Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase. Diabetes 2016 Oct; 65(10): 3075-3090. https://dx.doi.org/10.2337/db16-0023.  

“MicroRNAs (miRNAs) have a fundamental role in diabetic heart failure. The cardioprotective miRNA-133a (miR-133a) is downregulated, and contractility is decreased in diabetic hearts. Norepinephrine (NE) is a key catecholamine that stimulates contractility by activating β-adrenergic receptors (β-AR). NE is synthesized from tyrosine by the rate-limiting enzyme, tyrosine hydroxylase (TH), and tyrosine is catabolized by tyrosine aminotransferase (TAT).” Read More

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AroCell signs distribution agreement with Eagle Biosciences in the United States

by Eagle Biosciences
AroCell signs distribution agreement with Eagle Biosciences in the United States

 

 

AroCell AB (publ) announced today that a distribution
agreement has been signed with the New England-based company Eagle
Biosciences, for distribution of the AroCell TK 210 ELISA test in North
America.

The TK 210 ELISA test measures TK1 protein levels for valuable
information about the speed of cell turnover. As tumors have high cell
turnover, the test may provide valuable information for prognosis and
optimization of treatment strategy.

“We are delighted to partner with Eagle Biosciences for the
distribution of the TK 210 ELISA test”, states Jan Stålemark, AroCell
CEO. “Eagle Biosciences is a leading provider of ELISA assay kits in
North America, and has primary focus on providing innovative products
that aid medical research and clinical laboratories. This highly concurs
with our strategy to make the TK 210 ELISA test widely available for
investigational use in the US, in order to facilitate use of the product
in cancer research institutions as well as within the pharmaceutical
industry”.

The TK 210 ELISA test will be commercially available immediately
through Eagle Biosciences for investigational use only in the United
States.  The product can be found on the Eagle Biosciences website through the following link:

TK 210 ELISA

 

About AroCell

AroCell AB (AROC) is a Swedish company that develops
standardized modern blood tests to support the prognosis and follow up
of cancer patients. AroCell’s new technology is based on patented
methods to measure TK1 protein levels, which provide valuable
information about the speed of cell turnover. A tumor has high cell
turnover (speed of cell division and cell death) and as a result TK1 can
be detected in the blood with a simple laboratory test, called TK 210
ELISA. The test provides valuable clinical information for prognosis and
optimization of treatment strategy. The test may also be used for
monitoring disease relapse. For more information, please see www.arocell.com.
This information is information that AroCell is obliged to make public
pursuant to the EU Market Abuse Regulation. The information was
submitted for publication, through Jan Stålemark, at 11:45 CET on 6th October 2016. Redeye is AroCell:s Certified Adviser

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Rates of Neonatal Abstinence Syndrome Amid Efforts to Combat the Opioid Abuse Epidemic

by Eagle Biosciences

Image result for Rates of Neonatal Abstinence Syndrome Amid Efforts to Combat the Opioid Abuse Epidemic

image credit: currentsinbiology.tumblr.com

Brown JD, Doshi PA, Pauly NJ, Talbert JC. Rates of Neonatal Abstinence Syndrome Amid Efforts to Combat the Opioid Abuse Epidemic. JAMA Pediatr. Published online September 26, 2016. doi:10.1001/jamapediatrics.2016.2150.

The United States is experiencing a rapid increase in neonatal abstinence syndrome (NAS) caused by in utero exposure to prescription and illicit (heroin) opioids.1,2 Increases in NAS correlate with the well-documented increase in prescription opioid abuse.3 State and federal policy efforts to combat this increase in drug abuse have halted the increase in prescription drug abuse but are associated with an increase in illicit drug use.3 Read More

Source: (https://archpedi.jamanetwork.com/article.aspx?articleid=2556200)

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Texas Study Utilizes EagleBio’s DM1 Antibody Drug Conjugate (ADC) ELISA

by Eagle Biosciences

 

 

EagleBio’s DM1 Antibody Drug Conjugate (ADC) ELISA ASSAY Kit was recently used in a Texas Tech University Health Sciences Center study.  This assay is part of our Drug Monitoring Assay Kit line which offers a unique grouping of assays that provide incredible value to pre-clinical and clinical pharmacology studies, cancer research, and more specifically antitumor therapeutic investigation and more.

Yao H-P, Feng L, Zhou J-W, Zhang R-W, Wang M-H. Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment. American Journal of Cancer Research. 2016;6(5):937-956. PMID:27293990

“Blood samples were collected at different time intervals. DM1-coupled Zt/g4 was measured using a DM1 antibody ELISA kit (EagleBiosciences, Inc., Nashua, NH).”

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