Mouse Anti-Rat HCN1 (Clone S70) Monoclonal IgG1 Antibody
Hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) is a voltage-gated ion channel that contributes to the generation and regulation of rhythmic electrical activity in neurons. It is predominantly expressed in the cortex, hippocampus, and cerebellum—regions critically involved in cognition, memory, and motor control.
HCN1 channels play a key role in setting the resting membrane potential and modulating synaptic integration and neuronal excitability. In neurodegenerative diseases, such as Alzheimer’s and epilepsy-related cognitive decline, dysregulation of HCN1 expression or function has been linked to impaired synaptic plasticity and network dysfunction.
Altered HCN1 activity can disrupt the balance of excitatory and inhibitory signaling, contributing to neuronal hyperexcitability and excitotoxicity—both of which are implicated in neurodegeneration. Moreover, HCN1 has been shown to influence dendritic integration and long-term potentiation (LTP), processes essential for learning and memory.
Given its role in maintaining neuronal homeostasis and circuit stability, HCN1 is emerging as a potential therapeutic target for modulating brain excitability and protecting against neurodegenerative progression.
This Mouse Anti-Rat HCN1 (Clone S70) Monoclonal IgG1 Antibody is manufactured in Canada by StressMarq.
