Mouse IgG2A ELISA Kit
The Mouse IgG2a ELISA Kit is designed to quantitatively measure the IgG2a subclass of immunoglobulins in mouse serum, plasma, or culture supernatants. IgG2a is a key antibody isotype associated with Th1-type immune responses, particularly those driven by interferon-γ (IFN-γ). It plays an important role in antiviral and antibacterial immunity, mediating functions such as antibody-dependent cellular cytotoxicity (ADCC), opsonization, and complement activation. Because IgG2a levels correlate with cellular immune activation, this biomarker is commonly used to assess immune polarization and characterize the adaptive immune response in mouse models.
In research settings, the Mouse IgG2a ELISA Kit is widely used to study vaccine responses, infectious disease models, autoimmune conditions, and immunomodulatory therapies. Tracking IgG2a production helps researchers distinguish Th1-biased responses from Th2-driven pathways (often reflected by IgG1 or IgE levels). This makes the assay particularly valuable in investigations evaluating antigen-specific immunity, the effects of adjuvants, gene-knockout models, and therapeutic candidates that aim to shift or regulate immune balance. The kit’s sensitivity and reproducibility enable reliable quantification across longitudinal or high-throughput experimental studies.
Although this assay is intended for preclinical research rather than human diagnostics, IgG2a measurements provide insights that are highly relevant to translational immunology. Mouse IgG subclass responses often serve as surrogates for human IgG subclasses (such as IgG1 or IgG3) in the development of vaccines, monoclonal antibodies, and immune-modulating drugs. By characterizing Th1-skewed immunity in mouse models, the Mouse IgG2a ELISA Kit supports the design and optimization of therapies aimed at infectious diseases, cancer immunotherapy, and autoimmune regulation, ultimately contributing to the refinement of clinical strategies.
This Mouse IgG2A ELISA Kit is manufactured in USA by Eagle Biosciences.
Related products
