Intact PTH ELISA Kit
Intact Parathyroid Hormone (PTH) is an 84–amino acid peptide secreted by the parathyroid glands that plays a key role in calcium and phosphate homeostasis. The “intact” PTH assay specifically measures the biologically active full-length molecule (PTH 1–84), distinguishing it from inactive fragments that circulate in the blood. This measurement provides a more accurate reflection of parathyroid gland function compared to older assays that detected both intact hormone and C-terminal fragments. Intact PTH secretion is tightly regulated by serum calcium levels via a negative feedback loop involving the calcium-sensing receptor (CaSR) on parathyroid cells.
In clinical settings, intact PTH measurement is an essential biomarker for diagnosing and managing disorders of calcium metabolism. It is routinely used to differentiate causes of hypercalcemia (e.g., primary hyperparathyroidism vs. malignancy), to assess hypocalcemia (e.g., hypoparathyroidism or pseudohypoparathyroidism), and to monitor secondary hyperparathyroidism in patients with chronic kidney disease (CKD). In CKD, PTH monitoring helps guide treatment decisions aimed at preventing renal osteodystrophy and maintaining mineral balance.
In research contexts, intact PTH serves as a critical marker for studying bone metabolism, endocrine regulation, and the pathophysiology of mineral disorders. It is frequently used in studies examining the interactions among PTH, vitamin D, fibroblast growth factor 23 (FGF23), and calcium-phosphate homeostasis. Additionally, PTH assays are valuable in evaluating the efficacy of novel therapeutics that target the parathyroid axis or bone remodeling pathways. Overall, intact PTH remains a cornerstone biomarker bridging basic endocrine research and clinical practice.
This Intact PTH ELISA Kit is manufactured in USA by Eagle Biosciences.
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