High Sensitive Fetuin-A ELISA Kit

High-Sensitive Fetuin-A (hs-Fetuin-A) is a glycoprotein primarily synthesized by the liver and secreted into the bloodstream, where it functions as a multifunctional biomarker involved in metabolic regulation, inflammation, and vascular health. It belongs to the cystatin superfamily of protease inhibitors and acts as a systemic inhibitor of ectopic calcification by binding calcium and phosphate ions. Fetuin-A also plays a significant role in insulin signaling, as it can inhibit insulin receptor tyrosine kinase activity, linking it to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus.

In research settings, the measurement of hs-Fetuin-A—using high-sensitivity assays—allows for the detection of subtle variations in serum levels that may reflect early metabolic or inflammatory changes. Studies have explored its relationship with cardiovascular disease, non-alcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), where Fetuin-A serves as both a protective and pathogenic factor depending on the context. Elevated hs-Fetuin-A levels have been associated with insulin resistance and metabolic syndrome, while reduced levels are linked to vascular calcification and increased cardiovascular mortality in CKD patients.

In clinical applications, hs-Fetuin-A is being investigated as a potential biomarker for early diagnosis, disease monitoring, and risk stratification in metabolic and cardiovascular disorders. Its dual role—as an anti-calcification factor and a mediator of insulin resistance—makes it a valuable target for understanding the pathophysiology of cardiometabolic diseases. Incorporating hs-Fetuin-A measurements into clinical research may improve predictive models for disease progression and therapeutic response, ultimately guiding more personalized and preventive healthcare strategies.

This product is manufactured in USA by Eagle Biosciences.