Mouse Monoclonal Antibody to S-Adenosylmethionine (Clone 118-18) is for Research Use Only.
EagleBio’s Mouse Monoclonal Antibody To S-Adenosylmethionine (Clone 118-18) was recently used in a study by the Department of Molecular and Cellular Oncology at the University of Texas MD Anderson Cancer Center in Houston, Texas. This antibody has the following reactivities with related compounds: S-Adenosylmethionine: 100%, S-Adenosylhomocysteine: <1%, Adenosine: <1%, L-Methionine: <1%.
PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response
Posttranslational modifications to the intracellular domain of the EGFR are known to regulate EGFR functions; however, modifications to the extracellular domain and their effects remain relatively unexplored. Here, we determined that methylation at R198 and R200 of the EGFR extracellular domain by protein arginine methyltransferase 1 (PRMT1) enhances binding to EGF and subsequent receptor dimerization and signaling activation. Read More