Recent Publication in Sci Signal Citing EagleBio’s Biotin ELISA


 

The Vitamin Assay Kit line offered Eagle Biosciences provides unique and sensitive assays for measuring a variety of vitamin analytes. Our Biotin ELISA Assay Kit is a top-notch assay that provides a method that is easy to use, cost effective, and provides quantifiable results in under 3 hours. This kit has proven to be a valuable tool to researchers in various fields of study.

There is one recent study described below utilizing our Biotin ELISA Assay Kit, designed for the quantitative determination of Biotin (Vitamin H, Coenzyme R, Vitamin B7) in food products, cell culture, and tissue samples.

Publication:

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

Study Summary:

In normal adult cells, the structure at the ends of chromosomes, called the telomere, becomes progressively shorter with each replication cycle. When telomeres get too short or damaged, the cell stops dividing and becomes senescent. The enzyme telomerase maintains the integrity of telomeres, and phosphorylation stabilizes the catalytic subunit (called TERT) of this enzyme. In both normal fibroblasts and lung cancer cells, Panneer Selvam et al. found that binding of the phospholipid S1P to TERT mimicked protein phosphorylation and prevented TERT degration. Disrupting the interaction between S1P and TERT by either depleting S1P or mutating the interaction site in TERT impaired telomere maintenance and promoted senescence in cultured cells and decreased the growth of lung cancer cell xenografts in mice. Researchers utilized Eagle Biosciences’Biotin ELISA Assay Kit to measure levels of Biotin in Biotinylated S1P–bound hTERT proteins.

 

Related Products:

Vitamin Assay Kits

Vitamin Control Sets

Related News:

EagleBio’s 25-OH Vitamin D ELISA: Product Highlights

EagleBio Spotlight: Vitamin D

Interesting Study Reveals Possible Link Between Vitamin D and Autism

Eagle Biosciences Announces the Launch of Multispecies 25-OH Vitamin D ELISA Assay Kit

New Publications for Select Vitamin Assays Kits

EagleBio’s 25-OH Vitamin D ELISA: Product Highlights

May 15, 2014: Eagle Biosciences Adds to Vitamin Assay Menu

10 Reasons to Keep Up with Your Vitamin D Levels