Shikari®Atezolizumab ELISA Kit

$1,315.00

The Shikari®Atezolizumab ELISA Kit is intended for the quantitative determination of Atezolizumab in serum and plasma samples between the Cmin and Cmax range of concentrations. The Atezolizumab ELISA Kit is for research use only and not to be used for diagnostic procedures.

SKU: ATE-FD-TEC Category: Tags: , , ,

Atezolizumab is a humanized monoclonal IgG antibody designed to target and bind programmed death-ligand 1 (PD-L1), thereby blocking its interaction with the programmed death receptor-1 (PD-1) and B7.1. This mechanism of action prevents the suppression of the anti-tumor immune response, allowing T cells to recognize and attack tumor cells more effectively. Unlike some other immune checkpoint inhibitors, atezolizumab does not rely on antibody-dependent cellular cytotoxicity, focusing instead on modulating immune checkpoint pathways.

Clinically, atezolizumab is approved for the treatment of several cancers, including locally advanced or metastatic urothelial carcinoma, particularly in patients ineligible for cisplatin-based chemotherapy or those who have progressed after platinum-containing regimens. It is also indicated as a first-line treatment in combination with bevacizumab, paclitaxel, and carboplatin for non-small cell lung cancer (NSCLC) in patients without EGFR or ALK mutations. Additionally, it is used in combination with paclitaxel protein-bound for treating PD-L1-expressing locally advanced or metastatic triple-negative breast cancer.

In research and therapeutic settings, Therapeutic Drug Monitoring (TDM) of atezolizumab is increasingly valuable for optimizing individual dosage regimens. Monitoring blood levels can help assess treatment efficacy, manage toxicity, avoid drug-drug interactions, and evaluate patient compliance. Like all biologics, atezolizumab’s immunogenicity profile may be influenced by manufacturing processes, and the potential formation of anti-drug antibodies (ADAs) can alter pharmacokinetics, reduce efficacy, or trigger adverse events. Understanding these dynamics is crucial for effective treatment planning and for evaluating biosimilar development.

This product is manufactured in Turkey by Matriks Biotek.

Size 1 x 96 Well
Sensitivity 5 ng/mL
Dynamic Range 3- 300 ng/mL
Incubation Time 1 hour 10 minutes
Sample Type Serum, Plasma
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Atezolizumab, Tecentriq, anti-PD-L1 antibody, monoclonal anti-PD-L1, humanized IgG1 anti-PD-L1, MPDL3280A, PD-L1 immune checkpoint inhibitor, programmed death-ligand 1 blocker.
Instructions For Use https://eaglebio.com/wp-content/uploads/2025/06/ATE-FD-TEC-shikari-atezolizumab-elisa-instructions-for-use.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/06/ATE-FD-TEC-shikari-atezolizumab-elisa-kit-sds.pdf

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