Shikari® Tocilizumab ELISA Kit

$1,250.00

The Shikari® Tocilizumab ELISA Kit is intended for the quantitative determination of tocilizumab in serum and plasma samples between the Cmin and Cmax range of concentrations. The Shikari® Tocilizumab ELISA Kit is for Research Use Only and not for diagnostic procedures.

SKU: TOC-FD-ACT Category: Tags: , , ,

Tocilizumab is a recombinant, humanized monoclonal antibody that targets the human interleukin-6 (IL-6) receptor, effectively inhibiting IL-6-mediated signaling. IL-6 is a key pro-inflammatory cytokine involved in immune regulation, hematopoiesis, and nervous system functions, with dysregulated levels contributing to numerous autoimmune and inflammatory diseases. Tocilizumab binds to both soluble and membrane-bound forms of the IL-6 receptor (sIL-6R and mIL-6R), preventing IL-6 from exerting its pathological effects. The therapeutic response to tocilizumab has been significant in conditions such as rheumatoid arthritis, systemic lupus erythematosus, Crohn’s disease, juvenile idiopathic arthritis, and vasculitis.

Clinically, tocilizumab was approved by the FDA in 2010 and later for treating giant cell arteritis in 2017. Its use has shown benefits in reducing inflammation, improving symptoms, and normalizing laboratory markers of inflammation in patients with autoimmune diseases. In a placebo-controlled trial, patients with giant cell arteritis achieved sustained remission from weeks 12 to 52, with reduced reliance on corticosteroids. This supports the role of tocilizumab in managing severe inflammatory conditions with a high degree of immune involvement.

In research and clinical settings, therapeutic drug monitoring (TDM) is crucial for optimizing tocilizumab therapy. TDM ensures consistent serum levels, improving treatment outcomes and minimizing side effects. It is especially useful for managing drug efficacy, patient compliance, and drug interactions in complex autoimmune cases. Given the biologic nature of tocilizumab, and the variability introduced by manufacturing and immune responses (e.g., formation of antidrug antibodies), regular monitoring can significantly enhance the precision and safety of treatment regimens in both clinical trials and routine care.

This product is manufactured in Turkey by Matriks Biotek.

Size 1 x 96 Well
Sensitivity 0.003 µg/mL
Dynamic Range 100 – 3000 ng/mL
Incubation Time 70 minutes
Sample Type Serum, Plasma
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Tocilizumab, Actemra, Atlizumab, Anti-IL-6R monoclonal antibody, Humanized anti-human interleukin-6 receptor antibody, IL-6R inhibitor, TCZ, Monoclonal anti-IL-6R IgG1 antibody, Anti-interleukin-6 receptor antibody, RO4877533.
Instructions For Use https://eaglebio.com/wp-content/uploads/2025/06/TOC-FD-ACT-Shikari-Tocilizumab-ELISA-instructions-for-use.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/06/TOC-FD-ACT-Shikari-Tocilizumab-ELISA-safety-data-sheet-sds.pdf

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