Shikari® Rituximab Neutralizing Antibodies ELISA Kit

$2,120.00

The Shikari® Rituximab Neutralizing Antibodies ELISA Kit is intended for the detection of neutralizing antibodies to Rituximab in serum and plasma. The Shikari® Rituximab Neutralizing Antibodies ELISA Kit is for Research Use Only and not for diagnostic procedures.

Target capture neutralizing antibodies (NAbs) to rituximab are anti-drug antibodies (ADAs) that specifically inhibit rituximab’s pharmacological activity by preventing its binding to the CD20 antigen on B-lymphocytes. These NAbs can compromise therapeutic efficacy by sterically hindering the interaction or downstream signaling required for B-cell lysis, a key mechanism of action for rituximab. In some cases, NAbs may also cross-react with endogenous proteins, potentially impairing essential immune functions and triggering adverse effects.

In clinical and research settings, detecting and quantifying NAbs to rituximab is crucial for evaluating treatment response, guiding dosing strategies, and assessing immunogenicity risk. The SHIKARI® T-CAP NAb Assay provides a competitive ligand binding platform to monitor NAb presence by measuring drug-target interaction interference. A reduction in signal indicates the presence of NAbs that inhibit rituximab’s binding ability. These assays are used alongside ADA screening to ensure comprehensive immunogenicity assessment during biologic drug development and post-market surveillance.

From a biomarker perspective, the presence of rituximab-specific NAbs serves as a predictive indicator for altered pharmacokinetics, reduced therapeutic benefit, or potential hypersensitivity reactions. Monitoring these antibodies supports therapeutic drug monitoring (TDM) protocols, ensuring optimal patient outcomes through individualized treatment plans and early identification of drug resistance or adverse immune responses.

This product is manufactured in Turkey by Matriks Biotek.

Size 1 x 96 Well
Sensitivity 50 ng/mL
Dynamic Range cut-off
Incubation Time 140 minutes
Sample Type Serum, Plasma
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Anti-rituximab NAbs, rituximab-targeted neutralizing antibodies, rituximab-specific NAbs, anti-CD20 drug-neutralizing antibodies, rituximab-binding inhibitory antibodies, functional anti-rituximab antibodies, therapeutic-interfering antibodies to rituximab, neutralizing ADA to rituximab, target-blocking antibodies to rituximab, rituximab-reactive neutralizers.
Instructions For Use https://eaglebio.com/wp-content/uploads/2025/07/RIT-TCAP-Nab-RM-shikari-t-cap-nab-assay-rituximab-elisa-kit-instructions-for-use.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/07/RIT-TCAP-Nab-RM-shikari-t-cap-nab-assay-rituximab-sds.pdf

Product Citations