Shikari® Anti-Ramucirumab ELISA Kit

$1,445.00

The Shikari® Anti-Ramucirumab ELISA Kit is intended for the qualitative determination of specific antibodies to Ramucirumab in serum and plasma. The Shikari® Anti-Ramucirumab ELISA Kit is for Research Use Only and not for diagnostic procedures.

Anti-ramucirumab antibodies (ARAs) are a subset of anti-drug antibodies (ADAs) that may be generated in patients treated with ramucirumab, a monoclonal antibody targeting VEGFR-2. These antibodies are produced as part of an immune response against the therapeutic protein and may be either neutralizing or non-neutralizing in nature. Neutralizing ARAs are capable of blocking ramucirumab’s interaction with VEGFR-2, potentially diminishing its anti-angiogenic efficacy by restoring VEGF ligand signaling. Non-neutralizing ARAs may not directly interfere with VEGFR-2 binding but can still impact the drug’s pharmacokinetics and clearance.

In clinical settings, the presence of ARAs is a significant concern due to their potential to reduce therapeutic effectiveness and trigger adverse immune reactions. Monitoring for anti-ramucirumab is therefore important for evaluating treatment efficacy, safety, and guiding therapeutic decisions, particularly in patients showing reduced response or unexpected toxicity. Quantitative ADA and neutralizing antibody assays are used to detect and characterize the immunogenic response to ramucirumab.

In research, anti-ramucirumab antibodies serve as critical biomarkers in pharmacovigilance and immunogenicity profiling during drug development. Their detection enables early identification of immune-mediated alterations in drug activity, facilitating dose adjustments, combination strategies, and biosimilar development. These insights are especially valuable for optimizing precision therapy in oncology, where maintaining anti-angiogenic blockade is crucial for tumor growth suppression.

This product is manufactured in Turkey by Matriks Biotek.

Size 1 x 96 Well
Sensitivity Qualitative
Dynamic Range cut-off
Incubation Time 140 minutes
Sample Type Serum, Plasma
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Anti-ramucirumab antibodies, anti-VEGFR2 monoclonal antibody response, ramucirumab-reactive antibodies, ramucirumab-directed immune response, anti-VEGFR2 IgG, anti-VEGFR2 therapeutic antibodies, ramucirumab-binding antibodies, immunogenic antibodies to ramucirumab, host-derived anti-ramucirumab immunoglobulins, anti-angiogenic biologic antibodies.
Instructions For Use https://eaglebio.com/wp-content/uploads/2025/07/RAM-QLS-CYR-shikari-anti-ramucirumab-elisa-instructions-for-use.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/07/RAM-QLS-CYR-shikari-anti-ramucirumab-elisa-safety-data-sheet-sds.pdf

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